Increased prevalence of cardiovascular disease in idiopathic normal pressure hydrocephalus patients compared to a population-based cohort from the HUNT3 survey

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• 作者：Per Kristian Eide ; Are Hugo Pripp
• 关键词：Idiopathic normal pressure hydrocephalus ; Cardiovascular disease ; The HUNT3 Survey ; General population ; Arterial hypertension ; Angina pectoris ; Cardiac infarction ; Diabetes
• 刊名：Fluids and Barriers of the CNS
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：11
• 期：1
• 全文大小：1,370 KB
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• 刊物主题：Neurosciences; Neurology;
• 出版者：BioMed Central
• ISSN：2045-8118

文摘

Background Idiopathic normal pressure hydrocephalus (iNPH) is one of few types of dementia that can be treated with shunt surgery and cerebrospinal fluid (CSF) diversion. It is frequently present with cerebral vasculopathy; however, how the prevalence of cardiovascular disease compares between iNPH patients and the general population has not yet been established. Therefore, a case–control study was performed to examine whether the prevalence of cardiovascular disease (arterial hypertension, angina pectoris, cardiac infarction, and diabetes) was different in 440 iNPH patients, when compared to 43,387 participants of the Nord-Tr?ndelag Health 3 Survey (The HUNT3 Survey), which was considered as the general control population. Findings In iNPH patients aged 35-0 years, we found increased prevalence for arterial hypertension (males), angina pectoris (females and males), and cardiac infarction (males), as compared with the HUNT3 control group with significant odds ratio estimates. In addition, the prevalence of diabetes was increased in both age groups 35-0 years (males) and 70-0 years (females and males). Conclusions The data show significantly increased prevalence of cardiovascular disease iNPH patients, which provide evidence that cardiovascular disease is involved as an exposure in the development of iNPH.