Increased relative risk of acute pancreatitis in zolpidem users

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• 作者：Shih-Wei Lai ; Cheng-Li Lin ; Kuan-Fu Liao
• 关键词：Acute pancreatitis ; Alcoholism ; Biliary stone ; Diabetes ; Zolpidem
• 刊名：Psychopharmacology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：232
• 期：12
• 页码：2043-2048
• 全文大小：173 KB
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• 作者单位：Shih-Wei Lai (1) (2)
  Cheng-Li Lin (3) (4)
  Kuan-Fu Liao (5) (6)
  
  1. School of Medicine, China Medical University, Taichung, Taiwan
  2. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
  3. Department of Public Health, China Medical University, Taichung, Taiwan
  4. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
  5. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
  6. Department of Internal Medicine, Taichung Tzu Chi General Hospital, No.66, Sec. 1, Fongsing Road, Tanzi District, Taichung City, 427, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Objectives The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. Methods In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-4?years with the first episode of acute pancreatitis as cases and 18,140 subjects without acute pancreatitis matched for sex, age, and index year as controls. Immediate use of zolpidem was defined as subjects who received at least one prescription for zolpidem within 7?days before the date of diagnosing acute pancreatitis. The absence of zolpidem prescription was defined as never use. The odds ratio (OR) and 95?% confidence interval (CI) were used to evaluate the risk of acute pancreatitis associated with zolpidem use and other comorbidities. Results After adjustment for confounding factors, the multivariable logistic regression model demonstrated that the adjusted OR of acute pancreatitis was 7.20 for immediate use of zolpidem (95?% CI 5.81, 8.92), when compared to those with never use of zolpidem. In further analysis, as a reference of subjects with never use of zolpidem and without any of these comorbidities including alcoholism, biliary stone, diabetes mellitus, hepatitis B, hepatitis C, and hypertriglyceridemia, the adjusted OR was 18.04 in those with immediate use of zolpidem and without any comorbidity (95?% CI 12.71, 25.60). The OR increased to 30.32 in subjects with immediate use of zolpidem and with any comorbidity (95?% CI 23.71, 38.79). Conclusions Patients actively using zolpidem are at 7-fold increased odds of acute pancreatitis. Clinicians should be more cautious of acute pancreatitis risk among patients with any comorbidity studied when prescribing zolpidem.