Application of quinidine on rat sciatic nerve decreases the amplitude and increases the latency of evoked responses

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• 作者：Kuang-I Cheng (1) (2) (3)
  I-Ling Lin (4)
  Lin-Li Chang (5)
  I-Ming Jou (6)
  Chung-Sheng Lai (7)
  Jhi-Joung Wang (8)
  Hung-Chen Wang (1) (9)
  Aij-Lie Kwan (10) (11)
  
• 关键词：Quinidine ; Sciatic nerve ; Somato ; sensory evoked potential ; Compound muscle action potentials
• 刊名：Journal of Anesthesia
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：28
• 期：4
• 页码：559-568
• 全文大小：3,451 KB
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• 作者单位：Kuang-I Cheng (1) (2) (3)
  I-Ling Lin (4)
  Lin-Li Chang (5)
  I-Ming Jou (6)
  Chung-Sheng Lai (7)
  Jhi-Joung Wang (8)
  Hung-Chen Wang (1) (9)
  Aij-Lie Kwan (10) (11)
  
  1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  2. Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  3. Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  4. Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
  5. Department of Microbiology, Graduate Institute of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  6. Departments of Orthopedics, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  7. Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  8. Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan
  9. Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
  10. Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  11. Department of Neurosurgery, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, 807, Taiwan
  
• ISSN：1438-8359

文摘

Purpose Multi-modality electrophysiological techniques were performed to assess the effects of quinidine on peripheral nerve conduction. Methods Twenty-seven rats were treated with 1, 3, and 5?μmol quinidine in 0.1?ml 5?% glucose. The mixed-nerve somato-sensory evoked potential (M-SSEP), dermatomal-SSEP (D-SSEP), and compound muscle action potentials (CMAP) were evoked and recorded. After positioning Gelfoam strips saturated with quinidine and 5?% glucose around the left and right sciatic nerves, potentials were measured at baseline, immediately after treatment, every 15?min for the 1st hour, and every 30?min for the next 3?h. After 2 weeks, the walking behaviors and potentials were again analyzed and myelinated fibers in the sciatic nerve were counted. Results Quinidine applied directly to sciatic nerves reduced the amplitude and prolonged the latency in SSEPs and CMAP, compared to baseline and the contralateral right limbs (controls). This persisted for at least 4?h. After 2 weeks, electrophysiological tests and walking behavior showed no significant difference between the controls and experimental limbs. There was also no difference in the number of myelinated fibers in the sciatic nerves. Conclusions Quinidine decreases amplitude and prolongs latency in the sciatic nerve in a dose-related manner without local neural toxicity.