Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages
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- 作者：Su Jeong Kim ; Kyung-Tae Lee ; Hye-Eun Choi ; Tae Joung Ha…
- 关键词：anti ; inflammatory ; apigenin ; Chrysanthemum ; lipopolysaccharide ; luteolin
- 刊名：Food Science and Biotechnology
- 出版年：2015
- 出版时间：June 2015
- 年：2015
- 卷：24
- 期：3
- 页码：975-985
- 全文大小：641 KB
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Kyung-Tae Lee (2)
Hye-Eun Choi (2)
Tae Joung Ha (3)
Jung Hwan Nam (1)
Su Young Hong (1)
Dong Chil Chang (1)
Ki Sun Kim (4)
1. Highland Agriculture Research Institute, Rural Development Administration, Pyeongchang, Gangwon, 232-955, Korea
2. Department of Pharmaceutical Biochemistry, Kyung Hee University, Seoul, 130-701, Korea
3. Research Policy Bureau R&D Evaluation Division, Jeonju, Jeonbuk, 560-550, Korea
4. Department of Plant Science, Seoul National University, Seoul, 151-921, Korea - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Nutrition
Food Science - 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
- ISSN：2092-6456
文摘
This study was conducted to compare flavonoids and anti-inflammatory effects in Korean Chrysanthemum species. Leaf samples were identified using HPLC/MS with five flavonoids: luteolin-7-O-rutinoside, luteolin-7-O glucoside, apigenin-7-O-glucoside, apigenin, and acacetin-7-O-rutinoside. Leaf extracts from four taxa dose-dependently suppressed LPS-stimulated NO production significantly (p<0.05) inhibited production of LPS-induced PGE2 compared with controls. The extracts reduced the LPS-induced expressions of inducible NO synthase and cyclooxygenase-2 and inhibited LPS-induced tumor necrosis factor-α and interleukin-6 production for anti-inflammatory effects.