Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts

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• 作者：Lina Leiss ; Ercan Mutlu ; Anne Øyan ; Tao Yan ; Oleg Tsinkalovsky ; Linda Sleire…
• 关键词：Glioblastoma ; Tumour ; host interplay ; Tumour ; associated glial cells ; GFF ; NOD/scid mice ; Xenograft tumours ; Gene expression analysis ; Stem cell markers ; POU3F2
• 刊名：BMC Cancer
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：2980KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1471-2407
• 卷排序：17

文摘

BackgroundLittle is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers.