Endothelial function is impaired in conduit arteries of pannexin1 knockout mice

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• 作者：Dina Gaynullina (1) (2)
  Olga S Tarasova (1) (3)
  Oxana O Kiryukhina (1)
  Valery I Shestopalov (4) (5)
  Yuri Panchin (6) (7)
  
  1. Department of Human and Animal Physiology ; Faculty of Biology ; M.V. Lomonosov Moscow State University ; Leninskie Gory 1-12 ; 119234 ; Moscow ; Russia
  2. Department of Physiology ; Russian National Research Medical University ; Ostrovityanova str. 1 ; 117997 ; Moscow ; Russia
  3. State Research Center of the Russian Federation 鈥?Institute for Biomedical Problems RAS ; Khoroshevskoe shosse 76A ; 123007 ; Moscow ; Russia
  4. Department of Ophthalmology ; Bascom Palmer Eye Institute ; University of Miami ; Miller School of Medicine ; Miami ; Florida ; USA
  5. Vavilov Institute of General Genetics ; Russian Academy of Sciences ; Moscow ; Russian Federation
  6. Institute for Information Transmission Problems ; Russian Academy of Sciences ; Bolshoi Karetny pereulok 19-1 ; 127994 ; Moscow ; Russia
  7. Department of Mathematical Methods in Biology ; Belozersky Institute ; M.V.Lomonosov Moscow State University ; Leninskie Gory 1-40 ; 119991 ; Moscow ; Russia
  
• 关键词：Pannexin1 ; Endothelium ; Saphenous artery ; Knockout mice
• 刊名：Biology Direct
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：9
• 期：1
• 全文大小：231 KB
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• 刊物主题：Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1745-6150

文摘

Pannexin1 is ubiquitously expressed in vertebrate tissues, but the role it plays in vascular tone regulation remains unclear. We found that Pannexin1 expression level is much higher in the endothelium relative to smooth muscle of saphenous artery. The ability of endothelium-intact arteries for dilation was significantly impaired whereas contractile responses were considerably increased in mice with genetic ablation of Pannexin1. No such increased contractile responses were detected in the endothelium-denuded arteries. Combined, our findings suggest a new function of Pannexin1 as an important player in normal endothelium-dependent regulation of arterial tone, where it facilitates vessel dilation and attenuates constriction. Reviewed by Dr. Armen Mulkidjanian and Dr. Alexander Lobkovsky.