Interplay of curvature-induced micro- and nanodomain structures in multicomponent lipid bilayers

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• 作者：Leonie Brodbek ; Friederike Schmid
• 刊名：International Journal of Advances in Engineering Sciences and Applied Mathematics
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：8
• 期：2
• 页码：111-120
• 全文大小：701 KB
• 刊物类别：Engineering
• 刊物主题：Applied Mathematics and Computational Methods of Engineering
  
• 出版者：Springer India
• ISSN：0975-5616
• 卷排序：8

文摘

We discuss different mechanisms for curvature-induced domain formation in multicomponent lipid membranes and present a theoretical model that allows us to study the interplay between the domains. The model represents the membrane by two coupled monolayers, which each carry an additional order parameter field describing the local lipid composition. The spontaneous curvature of each monolayer is coupled to the local composition; moreover, the lipid compositions on opposing monolayers are coupled to each other. Using this model, we calculate the phase behavior of the bilayer in mean-field approximation. The resulting phase diagrams are surprisingly complex and reveal a variety of phases and phase transitions, including a decorated microdomain phase where nanodomains are aligned along the microdomain boundaries. Our results suggest that external membrane tension can be used to control the lateral organization of nanodomains (which might be associated with lipid “rafts”) in a multicomponent lipid bilayer.KeywordsLipid bilayersMulticomponent membranesLipid raftsGinzburg–Landau theoryElasticityCurvature