HIF-1α Genetic Variants and Protein Expression Confer the Susceptibility and Prognosis of Gliomas

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• 作者：Liang Yi (1)
  Xuwei Hou (2)
  Ji Zhou (1)
  Lunshan Xu (1)
  Qing Ouyang (1)
  Hong Liang (1)
  Zhaocong Zheng (3)
  Hongjie Chen (3)
  Minhui Xu (1)
  
• 关键词：Gliomas ; Hypoxia ; inducible factor ; 1α ; Polymorphism ; Risk ; Prognosis
• 刊名：NeuroMolecular Medicine
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：16
• 期：3
• 页码：578-586
• 全文大小：708 KB
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• 作者单位：Liang Yi (1)
  Xuwei Hou (2)
  Ji Zhou (1)
  Lunshan Xu (1)
  Qing Ouyang (1)
  Hong Liang (1)
  Zhaocong Zheng (3)
  Hongjie Chen (3)
  Minhui Xu (1)
  
  1. Department of Neurosurgery, Daping Hospital, Third Military Medical University, Chongqing, China
  2. Department of Cardiology, Hangzhou Hospital of Nanjing Medical University, Hangzhou, China
  3. Department of Neurosurgery, Fuzhou General Hospital of Xiamen University, Fuzhou, Fujian, China
  
• ISSN：1559-1174

文摘

To investigate the role of HIF-1α genetic polymorphism of c.1772C>T and c.1790G>A in the incidence and prognosis of gliomas in a Chinese cohort, a total of 387 gliomas patients and 437 age- and sex-matched healthy controls were recruited. The genetic polymorphism of c.1772C>T and c.1790G>A was determined. We found that the genotype distribution at c.1772C>T showed significant difference between patients and controls. Multivariable analyses showed a significantly higher risk for gliomas in 1772TT genotype carriers (odds ratio 2.68, with CC as reference). In addition, we also found a significantly higher risk for grade III?+?IV gliomas was observed in 1772TT genotype carriers (odds ratio 2.21, with CC as reference). The overall survival rates in patients with 1772TT or 1772CT genotype were markedly lower compared with patients with CC (both P?1772C>T polymorphisms may be used as a molecular marker for gliomas occurrence, grades and clinical outcome in gliomas patients.