Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion

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• 作者：Yunpeng Xie ; Dan Cui ; Linlin Sui ; Yuefei Xu ; Ningning Zhang…
• 关键词：FoxM1 ; Embryo ; JAR cells ; ERK ; Implantation ; Mouse
• 刊名：Cell and Tissue Research
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：362
• 期：2
• 页码：421-430
• 全文大小：4,904 KB
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• 作者单位：Yunpeng Xie (1)
  Dan Cui (1)
  Linlin Sui (1)
  Yuefei Xu (1)
  Ningning Zhang (2)
  Yanni Ma (1)
  Yinghua Li (1)
  Ying Kong (1)
  
  1. Department of Biochemistry and Molecular Biology, Dalian Medical University, 116044, Dalian, Liaoning, People’s Republic of China
  2. Department of Oncology, The First Affiliated Hospital of Dalian Medical University, 116011, Dalian, Liaoning, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

Successful placentation depends on the proper invasion of extravillous trophoblast (EVT) cells into maternal tissues. Previous reports have demonstrated that FoxM1 is oncogenic and plays important roles in angiogenesis, invasion, and metastasis. However, little is known about the roles of FoxM1 in the invasion of EVT cells. EGF, as a growth factor (epidermal growth factor), has been studied extensively in reproduction. JAR cells are a reliable model for studying early invasive trophoblast regulation. We have observed the relationship between EGF and FoxM1 in JAR cells by using specific inhibitors for the intervention in and study of potential signal pathways. We have also tested the ability of JAR cells to be influenced by the expression of FoxM1. Our data indicate that EGF promotes FoxM1 expression through the ERK signal pathway. Over-FoxM1 expression upregulates the ability of JAR cells to migrate and invade and vice versa. Our investigation of FoxM1 should provide new insights into the molecular mechanisms of EVT invasion.