Association of the Common Catalase Gene Polymorphism rs1001179 With Glycated Hemoglobin and Plasma Lipids in Hyperlipidemic Patients

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• 作者：Antonis Goulas ; Dimitrios Agapakis ; Athanassios Apostolidis…
• 关键词：Catalase ; Gene polymorphism ; rs1001179 ; Glycated hemoglobin ; Plasma lipids
• 刊名：Biochemical Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：55
• 期：1
• 页码：77-86
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Human Genetics; Biochemistry, general; Zoology; Medical Microbiology;
• 出版者：Springer US
• ISSN：1573-4927
• 卷排序：55

文摘

Catalase represents perhaps the most effective antioxidant defense in the body under conditions of increased oxidative stress, and rs1001179 (CAT-262C >T) is its most extensively studied gene polymorphism. Using an established PCR–RFLP method for genotyping, we examined the association of rs1001179 with glycated hemoglobin (HbA1c) and plasma lipids using univariate analyses with age, sex, body mass index (BMI), smoking, and alcohol abuse as covariates, in a group of dyslipidemic patients from northern Greece. Our results suggest that the TT genotype is a risk factor for increased HbA1c and plasma triglycerides, and that this association is modulated by the BMI and/or age of the patients.