[11C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice

详细信息    查看全文

• 作者：Lei Li ; Li Che ; Chunmei Wang ; Joseph E. Blecha ; Xiaolei Li…
• 刊名：Molecular Imaging and Biology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：18
• 期：3
• 页码：360-367
• 全文大小：3,189 KB
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：18

文摘

PurposeAltered metabolism, including increased glycolysis and de novo lipogenesis, is one of the hallmarks of cancer. Radiolabeled nutrients, including glucose and acetate, are extensively used for the detection of various tumors, including hepatocellular carcinomas (HCCs). High signal of [11C]acetate positron emission tomography (PET) in tumors is often considered to be associated with increased expression of fatty acid synthase (FASN) and increased de novo lipogenesis in tumor tissues. Defining a subset of tumors with increased [11C]acetate PET signal and thus increased lipogenesis was suggested to help select a group of patients, who may benefit from lipogenesis-targeting therapies.