A new sensitivity-based adaptive control vector parameterization approach for dynamic optimization of bioprocesses

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• 作者：Liwei Wang ; Xinggao Liu ; Zeyin Zhang
• 关键词：Dynamic optimization ; Bioprocesses ; Control vector parameterization ; Adaptive grid refinement ; Sensitivity
• 刊名：Bioprocess and Biosystems Engineering
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：2
• 页码：181-189
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Biotechnology; Industrial and Production Engineering; Environmental Engineering/Biotechnology; Industrial Chemistry/Chemical Engineering; Food Science;
• 出版者：Springer Berlin Heidelberg
• ISSN：1615-7605
• 卷排序：40

文摘

Dynamic optimization is a very effective way to increase the profitability or productivity of bioprocesses. As an important method of dynamic optimization, the control vector parameterization (CVP) approach needs to select an optimal discretization level to balance the computational cost with the desired solution quality. A new sensitivity-based adaptive refinement method is therefore proposed, by which new time grid points are only inserted where necessary and unnecessary points are eliminated so as to obtain economic and effective discretization grids. Moreover, considering that traditional refinement methods may cost a lot to get the high-quality solutions of some bioprocess problems, whose performance indices are sensitive to some significant time points, an optimization technique is further proposed and embedded into the new sensitivity-based CVP approach to efficiently solve these problems. The proposed methods are applied to two well-known bioprocess optimization problems and the results illustrate their effectiveness.