Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in plants

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• 作者：Shucen Wan ; Liwen Jiang
• 关键词：Plant ; ER stress ; UPR ; ATF6 ; IRE1
• 刊名：Protoplasma
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：253
• 期：3
• 页码：753-764
• 全文大小：743 KB
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• 作者单位：Shucen Wan (1) (3)
  Liwen Jiang (2) (3)
  
  1. Molecular Biotechnology Program, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
  3. School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
  2. Centre for Cell and Developmental Biology and State Key Laboratory of Agrobiotechnology, School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Plant Sciences
  Zoology
  
• 出版者：Springer Wien
• ISSN：1615-6102

文摘

Being a major factory for protein synthesis, assembly, and export, the endoplasmic reticulum (ER) has a precise and robust ER quality control (ERQC) system monitoring its product line. However, when organisms are subjected to environmental stress, whether biotic or abiotic, the levels of misfolded proteins may overwhelm the ERQC system, tilting the balance between the capacity of and demand for ER quality control and resulting in a scenario termed ER stress. Intense or prolonged ER stress may cause damage to the ER as well as to other organelles, or even lead to cell death in extreme cases. To avoid such serious consequences, cells activate self-rescue programs to restore protein homeostasis in the ER, either through the enhancement of protein-folding and degradation competence or by alleviating the demands for such reactions. These are collectively called the unfolded protein response (UPR). Long investigated in mammalian cells and yeasts, the UPR is also of great interest to plant scientists. Among the three branches of UPR discovered in mammals, two have been studied in plants with plant homologs existing of the ER-membrane-associated activating transcription factor 6 (ATF6) and inositol-requiring enzyme 1 (IRE1). This review discusses the molecular mechanisms of these two types of UPR in plants, as well as the consequences of insufficient UPR, with a focus on experiments using model plants.