Hemoglobin A1c as a marker for identifying diabetes and cardiovascular risk factors: the China Health and Nutrition Survey 2009

详细信息    查看全文

• 作者：Xingxing Sun (1)
  Tingting Du (2)
  Rui Huo (2)
  Lixian Xu (1)
  
• 关键词：Hemoglobin A1c ; Fasting plasma glucose ; Diabetes ; Diagnosis
• 刊名：Acta Diabetologica
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：51
• 期：3
• 页码：353-360
• 全文大小：
• 参考文献：1. American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33(Suppl 1):S62–S69 CrossRef
  2. Lipska KJ, De Rekeneire N, Van Ness PH, Johnson KC, Kanaya A, Koster A, Strotmeyer ES, Goodpaster BH, Harris T, Gill TM, Inzucchi SE (2010) Identifying dysglycemic states in older adults: implications of the emerging use of hemoglobin A1c. J Clin Endocrinol Metab 95:5289-295 CrossRef
  3. Wang W, Lee ET, Howard BV, Fabsitz RR, Devereux RB, Welty TK (2011) Fasting plasma glucose and hemoglobin A1c in identifying and predicting diabetes: the strong heart study. Diabetes Care 34:363-68 CrossRef
  4. Bianchi C, Miccoli R, Bonadonna RC, Giorgino F, Frontoni S, Faloia E, Marchesini G, Dolci MA, Cavalot F, Cavallo GM, Leonetti F, Del Prato S (2012) Pathogenetic mechanisms and cardiovascular risk: differences between HbA1c and oral glucose tolerance test for the diagnosis of glucose tolerance. Diabetes Care 35:2607-612 CrossRef
  5. Ziemer DC, Kolm P, Weintraub WS, Vaccarino V, Rhee MK, Twombly JG, Narayan KM, Koch DD, Phillips LS (2010) Glucose-independent, black-white differences in hemoglobin A1c levels: a cross-sectional analysis of 2 studies. Ann Intern Med 152:770-77 CrossRef
  6. Herman WH, Ma Y, Uwaifo G, Haffner S, Kahn SE, Horton ES, Lachin JM, Montez MG, Brenneman T, Barrett-Connor E (2007) Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care 30:2453-457 CrossRef
  7. Abdul-Ghani MA, Tripathy D, DeFronzo RA (2006) Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 29:1130-139 CrossRef
  8. Abdul-Ghani MA, Sabbah M, Kher J, Minuchin O, Vardi P, Raz I (2006) Different contributions of insulin resistance and beta-cell dysfunction in overweight Israeli Arabs with IFG and IGT. Diabetes Metab Res Rev 22:126-30 CrossRef
  9. Dickinson S, Colagiuri S, Faramus E, Petocz P, Brand-Miller JC (2002) Postprandial hyperglycemia and insulin sensitivity differ among lean young adults of different ethnicities. J Nutr 132:2574-579
  10. Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, Zimmet P, Son HY (2006) Epidemic obesity and type 2 diabetes in Asia. Lancet 368:1681-688 CrossRef
  11. Popkin BM, Du S, Zhai F, Zhang B (2009) Cohort profile: the China health and nutrition survey–monitoring and understanding socio-economic and health change in China, 1989-011. Int J Epidemiol 39:1435-440 CrossRef
  12. Alberti KG, Zimmet P, Shaw J (2005) The metabolic syndrome—a new worldwide definition. Lancet 366:1059-062 CrossRef
  13. van’t Riet E, Alssema M, Rijkelijkhuizen JM, Kostense PJ, Nijpels G, Dekker JM (2009) Relationship between A1C and glucose levels in the general Dutch population: the new Hoorn study. Diabetes Care 33:61-6 CrossRef
  14. Sato KK, Hayashi T, Harita N, Yoneda T, Nakamura Y, Endo G, Kambe H (2009) Combined measurement of fasting plasma glucose and A1C is effective for the prediction of type 2 diabetes: the Kansai Healthcare Study. Diabetes Care 32:644-46 CrossRef
  15. Matsushita K, Blecker S, Pazin-Filho A, Bertoni A, Chang PP, Coresh J, Selvin E (2010) The association of hemoglobin a1c with incident heart failure among people without diabetes: the atherosclerosis risk in communities study. Diabetes 59:2020-026 CrossRef
  16. Schottker B, Raum E, Rothenbacher D, Muller H, Brenner H (2011) Prognostic value of haemoglobin A1c and fasting plasma glucose for incident diabetes and implications for screening. Eur J Epidemiol 26:779-87 CrossRef
  17. Monnier L, Lapinski H, Colette C (2003) Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care 26:881-85 CrossRef
  18. Kanat M, Winnier D, Norton L, Arar N, Jenkinson C, Defronzo RA, Abdul-Ghani MA (2011) The relationship between {beta}-cell function and glycated hemoglobin: results from the veterans administration genetic epidemiology study. Diabetes Care 34:1006-010 CrossRef
  19. Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, Kodama S, Shimano H, Yamada N, Hara S, Sone H (2012) High normal HbA(1c) levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8). Diabet Med 29:1285-290 CrossRef
  20. Godsland IF, Jeffs JA, Johnston DG (2004) Loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157-166 CrossRef
  21. Abdul-Ghani MA, Matsuda M, Jani R, Jenkinson CP, Coletta DK, Kaku K, DeFronzo RA (2008) The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance. Am J Physiol Endocrinol Metab 295:E401–E406 CrossRef
  22. Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA (2005) beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 90:493-00 CrossRef
  23. Nathan DM, Davidson MB, DeFronzo RA, Heine RJ, Henry RR, Pratley R, Zinman B (2007) Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care 30:753-59 CrossRef
  24. Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA (2006) Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes 55:1430-435 CrossRef
  25. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23:57-3 CrossRef
  26. Ginde AA, Cagliero E, Nathan DM, Camargo CA Jr (2008) Value of risk stratification to increase the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population. J Gen Intern Med 23:1346-353 CrossRef
  27. Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Zhou Z, Shan G, He J (2010) Prevalence of diabetes among men and women in China. N Engl J Med 362:1090-101 CrossRef
  28. Boronat M, Saavedra P, Lopez-Rios L, Riano M, Wagner AM, Novoa FJ (2010) Differences in cardiovascular risk profile of diabetic subjects discordantly classified by diagnostic criteria based on glycated hemoglobin and oral glucose tolerance test. Diabetes Care 33:2671-673 CrossRef
  29. Marini MA, Succurro E, Arturi F, Ruffo MF, Andreozzi F, Sciacqua A, Lauro R, Hribal ML, Perticone F, Sesti G (2011) Comparison of A1C, fasting and 2-h post-load plasma glucose criteria to diagnose diabetes in Italian Caucasians. Nutr Metab Cardiovasc Dis 22:561-66 CrossRef
  30. Cheng YJ, Gregg EW, Geiss LS, Imperatore G, Williams DE, Zhang X, Albright AL, Cowie CC, Klein R, Saaddine JB (2009) Association of A1C and fasting plasma glucose levels with diabetic retinopathy prevalence in the US population: implications for diabetes diagnostic thresholds. Diabetes Care 32:2027-032 CrossRef
  31. Droumaguet C, Balkau B, Simon D, Caces E, Tichet J, Charles MA, Eschwege E (2006) Use of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care 29:1619-625 CrossRef
  32. Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, Coresh J, Brancati FL (2010) Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med 362:800-11 CrossRef
  33. Wang H, Shara NM, Lee ET, Devereux R, Calhoun D, de Simone G, Umans JG, Howard BV (2011) Hemoglobin A1c, fasting glucose, and cardiovascular risk in a population with high prevalence of diabetes: the strong heart study. Diabetes Care 34:1952-958 CrossRef
  34. Ridker PM, Hennekens CH, Buring JE, Rifai N (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836-43 CrossRef
  
• 作者单位：Xingxing Sun (1)
  Tingting Du (2)
  Rui Huo (2)
  Lixian Xu (1)
  
  1. Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi’an, 710032, China
  2. Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  
• ISSN：1432-5233

文摘

Hemoglobin A1c (HbA1c) has been recommended as an optional method for diagnosing diabetes. The impact of HbA1c on the diagnosis of diabetes has not been evaluated in China, a country with the greatest number of people with diabetes in the world. Hence, we aim to examine how well HbA1c performs as compared with fasting plasma glucose (FPG) for diagnosing diabetes in Chinese population. We conducted a cross-sectional analysis of 7,641 Chinese men and women aged ?8?years using data from the China Health and Nutrition Survey 2009 in which FPG and standardized HbA1c were measured. HbA1c was measured with high-performance liquid chromatography system. Diabetes is defined as having FPG ??mmol/l or HbA1c ?.5?%. Overall, 5.0 and 5.8?% had undiagnosed diabetes by FPG ??mmol/l and HbA1c ?.5?%, respectively. Overlap between HbA1c- and FPG-based diagnosis of diabetes was limited (n?=?214, 34.9?%). Similar trends were noted in both genders, all age groups, urban/rural settings, regions, body mass index (BMI) categories, waist circumference (WC) groups, and blood pressure status. Solely HbA1c-defined individuals exhibited higher levels of BMI, WC, total cholesterol, and hypersensitive C-reactive protein and lower levels of homeostasis model assessment of insulin resistance. We note limited overlap between FPG- and HbA1c-based diagnosis of diabetes. The limited overlap between FPG- and HbA1c-based diagnosis of diabetes persisted in each evaluated subgroup. HbA1c criterion for the diagnosis of diabetes identifies individuals with a worse cardiovascular risk profile compared with FPG.