Spanish consensus for the management of patients with anaplastic cell thyroid carcinoma
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- 作者：P. Jiménez-Fonseca ; J. M. Gómez Saez…
- 关键词：Anaplastic thyroid carcinoma ; Poorly differentiated thyroid carcinoma ; Genetic abnormalities ; Distant metastases
- 刊名：Clinical and Translational Oncology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：19
- 期：1
- 页码：12-20
- 全文大小：
- 刊物主题：Oncology;
- 出版者：Springer International Publishing
- ISSN：1699-3055
- 卷排序：19
文摘
Anaplastic thyroid cancer (ATC) is the most aggressive solid tumor and almost uniformly lethal in humans. The Boards of the Thyroid Cancer Group of the Spanish Society of Endocrinology and Nutrition and the Grupo Español de Enfermedades Huérfanas e Infrecuentes of the Spanish Society of Oncology requested that an independent task force draft a more comprehensive consensus statement regarding ATC. All relevant literature was reviewed, including serial PubMed searches together with additional articles. This is the first, comprehensive Spanish consensus statement for ATC and includes the characteristics, diagnosis, initial evaluation, treatment goals, recommendations and modalities for locoregional and advanced disease, palliative care options, surveillance, and long-term monitoring. Newer systemic therapies are being investigated, but more effective combinations are needed to improve patient outcomes. Though more aggressive radiotherapy has reduced locoregional recurrences, median overall survival has not improved in more than 50 years.