Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system
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- 作者：Qing Liu ; Fa-Cai Li ; Hany M. Elsheikha ; Miao-Miao Sun ; Xing-Quan Zhu
- 关键词：Toxoplasma gondii ; TgGRA15 ; Host ; pathogen interaction ; Yeast ; two ; hybrid ; Luzp1 ; AW209491
- 刊名：Parasites & Vectors
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：1833KB
- 刊物主题：Parasitology; Entomology; Tropical Medicine; Infectious Diseases; Veterinary Medicine/Veterinary Science; Virology;
- 出版者：BioMed Central
- ISSN：1756-3305
- 卷排序：10
文摘
BackgroundToxoplasma gondii, an obligate intracellular protozoan parasite, possesses the remarkable ability to co-opt host cell machinery in order to maintain its intracellular survival. This parasite can modulate signaling pathways of its host through the secretion of polymorphic effector proteins localized in the rhoptry and dense granule organelles. One of such effectors is T. gondii type II-specific dense granule protein 15, TgGRA15, which activates NF-κB pathway. The aim of the present study was to identify the host interaction partner proteins of TgGRA15.