Influence of HPMC K100LV and Compritol® HD5 ATO on Drug Release and Rheological Behavior of HPMC K4M Matrix Tablets
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- 作者：Rania Hamed ; Ali Al-Samydai ; Tamadur Al Baraghthi…
- 关键词：Controlled ; release tablets ; Hydroxypropyl methylcellulose ; PEGylated glyceryl behenate (Compritol® HD5 ATO) ; Release kinetics ; Swelling ; Erosion ; Viscoelastic properties
- 刊名：Journal of Pharmaceutical Innovation
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：12
- 期：1
- 页码：62-75
- 全文大小：
- 刊物主题：Pharmacology/Toxicology; Industrial and Production Engineering; Biotechnology; Biochemical Engineering;
- 出版者：Springer US
- ISSN：1939-8042
- 卷排序：12
文摘
PurposeThe objectives of this study were to develop once-a-day oral controlled-release tablets of quetiapine fumarate (QF) and to determine the effect of polymer type, viscosity grade, polymer ratio, and polymer rheological properties on the rate of QF release from hydroxypropyl methylcellulose (HPMC) matrix tablets.