Theranostic multimodal potential of magnetic nanoparticles actuated by non-heating low frequency magnetic field in the new-generation nanomedicine

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• 作者：Yuri I. Golovin ; Natalia L. Klyachko…
• 关键词：Functionalized magnetic nanoparticles ; Non ; heating low frequency magnetic fields ; New ; generation nanomedicine ; Theranostics ; Diagnostics ; therapeutics ; and monitoring capabilities
• 刊名：Journal of Nanoparticle Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：2
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nanotechnology; Inorganic Chemistry; Characterization and Evaluation of Materials; Physical Chemistry; Optics, Lasers, Photonics, Optical Devices;
• 出版者：Springer Netherlands
• ISSN：1572-896X
• 卷排序：19

文摘

The scope of this review involves one of the most promising branches of new-generation biomedicine, namely magnetic nanotheranostics using remote control of functionalized magnetic nanoparticles (f-MNPs) by means of alternating magnetic fields (AMFs). The review is mainly focused on new approach which utilizes non-heating low frequency magnetic fields (LFMFs) for nanomechanical actuation of f-MNPs. This approach is compared to such traditional ones as magnetic resonance imaging (MRI) and radio-frequency (RF) magnetic hyperthermia (MH) which utilize high frequency heating AMF. The innovative principles and specific models of non-thermal magnetomechanical actuation of biostructures by MNP rotational oscillations in LFMF are described. The discussed strategy allows biodistribution monitoring in situ, delivering drugs to target tissues and releasing them with controlled rate, controlling biocatalytic reaction kinetics, inducing malignant cell apoptosis, and more. Optimization of both LFMF and f-MNP parameters may lead to dramatic improvement of treatment efficiency, locality, and selectivity on molecular or cellular levels and allow implementing both drug and drugless, i.e., pure nanomechanical therapy, in particular cancer therapy. The optimal parameters within this approach differ significantly from those used in MH or MRI because of the principal difference in the f-MNP actuation modes. It is shown that specifically designed high gradient, steady magnetic field enables diagnostic and therapeutic LFMF impact localization in the deep tissues within the area ranging from a millimeter to a few centimeters and 3D scanning of affected region, if necessary.