Giant esophageal gastrointestinal stromal tumor: report of a case

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• 作者：Akira Nakano ; Yasunori Akutsu ; Kiyohiko Shuto ; Masaya Uesato…
• 关键词：Gastrointestinal stromal tumor ; Esophagus ; Prognostic factor
• 刊名：Surgery Today
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：45
• 期：2
• 页码：247-252
• 全文大小：920 KB
• 参考文献：1. Rubin BP, Heinrich MC, Corless CL. Gastrointestinal stromal tumour. Lancet. 2007;369:1731-1. CrossRef
  2. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006;130:1466-8.
  3. Miettinen M, Majidi M, Lasota J. Pathology and diagnosis criteria of gastrointestinal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas. Am J Surg Pathol. 2000;24:211-2. CrossRef
  4. Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer. 2002;38(suppl 5):S39-1. CrossRef
  5. Lee HJ, Park SI, Kim DK, Kim YH. Surgical resection of esophageal gastrointestinal stromal tumors. Ann Thorac Surg. 2009;87(5):1569-1. CrossRef
  6. Rosai J. Stromal tumors. Ackerman’s surgical pathology. 8th ed. Chicago: Mosby; 1996. p. 645-.
  7. Mittinen M, Sarlomo-Rikala M, Lasota J. Gastointestinal stromal tumours. Ann Chir Gynaecol. 1998;87:278-1.
  8. Nishida T, Hirota S. Biological and clinical review of stromal tumors in the gastrointestinal tract. Histol Histopathol. 2000;15:1293-01.
  9. Miettinen M, Blay JY, Sobin LH. Mesnchymal tumors of the stomach. In: Stanley R, editor. Pathology and genetics of tumors of the digestive system. Lyon: IARC Press; 2000. p. 62-.
  10. Ahmet B, Ekrem K, Burain C. Giant gastrointestinal stromal tumor of the esophagus presenting with dyspnea. J Thorac Cardiovasc Surg. 2006;131:1198-. CrossRef
  11. Arantes V, Logrono R, Faruqi S, Ahmed I, Waxman I, Bhutani MS. Endoscopic sonographically guided fine-needle aspiration yield in submucosal tumors of the gastrointestinal tract. J Ultrasound Med. 2004;23:1141-0.
  12. Vander Noot MR III, Eloubeidi MA, Chen VK, Eltoum I, Jhala D, Jhala N, et al. Diagnosis of gastrointestinal tract lesions by endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer. 2004;102:157-3. CrossRef
  13. Demetri GD, Baker LH, Benjamin R, National Comprehensive Cancer Network, et al. Soft tissue sarcoma clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2005;3:158-4.
  14. Yasunori A, Hisahiro M. The significance of lymph node status as a prognostic factor for esophageal cancer. Surg Today. 2011;41:1190-. CrossRef
  15. Matsumoto S, Takayama T, Wakatsuki K, Enomoto K, Tanaka T, Migita K, Takano M, Nakajima Y. An esophageal gastrointestinal stromal tumor with regional lymph node metastasis. Esophagus. 2010;7(2):115-. CrossRef
  16. DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: reccurence patterns and prognostic factors for survival. Ann Surg. 2000;231:51-. CrossRef
  17. Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol. 2005;29:52-8. CrossRef
  18. Aparicio T, Boige V, Sabourin JC, Crenn P, Ducreux M, Le Cesne A, et al. Prognostic factors after surgery of primary resectable gastrointestinal stromal tumours. Eur J Surg Oncol. 2004;30:1098-03. CrossRef
  19. Yan H, Marchettini P, Acherman YI, Gething SA, Brun E, Sugarbaker PH. Prognotic assessment of gastrointestinal stromal tumor. Am J Clin Oncol. 2003;26:221-.
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Abdominal Surgery
  Thoracic Surgery
  Vascular Surgery
  Cardiac Surgery
  Surgical Oncology
  
• 出版者：Springer Japan
• ISSN：1436-2813

文摘

Gastrointestinal stromal tumors (GISTs) rarely arise in the esophagus, where carcinoma is the most common malignant neoplasm and leiomyoma is the most common benign tumor. Because of their rarity, the clinical course and treatment of esophageal GISTs are poorly understood. These lesions are generally thought to carry a poor prognosis, making the differential diagnosis of other common mesenchymal neoplasms essential, for both prognostic and therapeutic reasons. We report a case of successfully resected giant esophageal GIST, thought to be the largest resected GIST reported in Japan. The patient was a 65-year-old woman, in whom upper gastrointestinal endoscopy found a 180-mm submucosal tumor in the lower thoracic esophagus, extending just below the aortic arch. We diagnosed esophageal GIST, and the patient underwent middle and lower esophagectomy via left thoracotomy, followed by gastric tube reconstruction. The tumor was resected completely. Histopathological and immunohistochemical staining confirmed that the tumor was a high-risk lesion, and treatment with imatinib was initiated. Computed tomography showed liver metastasis 5?months later, but the patient is doing well 24?months after surgery.