Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms

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• 作者：Jaspreet Kaur ; Shweta Sharma ; Manpreet Sandhu ; Saurabh Sharma
• 刊名：Inflammopharmacology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：24
• 期：4
• 页码：133-143
• 全文大小：1,737 KB
• 刊物主题：Pharmacology/Toxicology; Immunology; Rheumatology; Gastroenterology; Dermatology; Allergology;
• 出版者：Springer Basel
• ISSN：1568-5608
• 卷排序：24

文摘

BackgroundsIncrease in SP release as a function of hypoxia of the rat carotid body is a tissue response to ischemia that leads to neurogenic inflammation and cognitive deficits. Substance P-mediated inflammation is reported to attenuate the neuroprotective PPAR-γ. This study was undertaken to investigate the effect of aprepitant, a substance P-NK1 receptor antagonist in bilateral carotid artery occlusion (BCCAO)-induced ischaemic brain injury and vascular dementia.