Genome-wide association study of endometrial cancer in E2C2
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- 作者：Immaculata De Vivo (1) (2)
Jennifer Prescott (1)
Veronica Wendy Setiawan (3)
Sara H. Olson (4)
Nicolas Wentzensen (5)
John Attia (7) (8)
Amanda Black (5)
Louise Brinton (5)
Chu Chen (9)
Constance Chen (2)
Linda S. Cook (10) (11)
Marta Crous-Bou (1) (2)
Jennifer Doherty (12)
Alison M. Dunning (13) (14)
Douglas F. Easton (14) (15)
Christine M. Friedenreich (11)
Montserrat Garcia-Closas (14)
Mia M. Gaudet (16)
Christopher Haiman (3)
Susan E. Hankinson (1) (17)
Patricia Hartge (5)
Brian E. Henderson (3)
Elizabeth Holliday (18) (19)
Pamela L. Horn-Ross (20)
David J. Hunter (2)
Loic Le Marchand (21)
Xiaolin Liang (4)
Jolanta Lissowska (22)
Jirong Long (23)
Lingeng Lu (24)
Anthony M. Magliocco (25)
Mark McEvoy (7)
Tracy A. O’Mara (6)
Irene Orlow (4)
Jodie N. Painter (6)
Loreall Pooler (3)
Radhai Rastogi (4)
Timothy R. Rebbeck (26)
Harvey Risch (24)
Carlotta Sacerdote (27) (28)
Fredrick Schumacher (20)
Rodney J. Scott (19) (29)
Xin Sheng (3)
Xiao-ou Shu (23)
Amanda B. Spurdle (6)
Deborah Thompson (14) (15)
David VanDen Berg (3)
Noel S. Weiss (30)
Lucy Xia (3)
Yong-Bing Xiang (31)
Hannah P. Yang (5)
Herbert Yu (21)
Wei Zheng (23)
Stephen Chanock (5)
Peter Kraft (2) - 刊名：Human Genetics
- 出版年：2014
- 出版时间：February 2014
- 年：2014
- 卷：133
- 期：2
- 页码：211-224
- 全文大小：764 KB
- 作者单位：Immaculata De Vivo (1) (2)
Jennifer Prescott (1)
Veronica Wendy Setiawan (3)
Sara H. Olson (4)
Nicolas Wentzensen (5)
John Attia (7) (8)
Amanda Black (5)
Louise Brinton (5)
Chu Chen (9)
Constance Chen (2)
Linda S. Cook (10) (11)
Marta Crous-Bou (1) (2)
Jennifer Doherty (12)
Alison M. Dunning (13) (14)
Douglas F. Easton (14) (15)
Christine M. Friedenreich (11)
Montserrat Garcia-Closas (14)
Mia M. Gaudet (16)
Christopher Haiman (3)
Susan E. Hankinson (1) (17)
Patricia Hartge (5)
Brian E. Henderson (3)
Elizabeth Holliday (18) (19)
Pamela L. Horn-Ross (20)
David J. Hunter (2)
Loic Le Marchand (21)
Xiaolin Liang (4)
Jolanta Lissowska (22)
Jirong Long (23)
Lingeng Lu (24)
Anthony M. Magliocco (25)
Mark McEvoy (7)
Tracy A. O’Mara (6)
Irene Orlow (4)
Jodie N. Painter (6)
Loreall Pooler (3)
Radhai Rastogi (4)
Timothy R. Rebbeck (26)
Harvey Risch (24)
Carlotta Sacerdote (27) (28)
Fredrick Schumacher (20)
Rodney J. Scott (19) (29)
Xin Sheng (3)
Xiao-ou Shu (23)
Amanda B. Spurdle (6)
Deborah Thompson (14) (15)
David VanDen Berg (3)
Noel S. Weiss (30)
Lucy Xia (3)
Yong-Bing Xiang (31)
Hannah P. Yang (5)
Herbert Yu (21)
Wei Zheng (23)
Stephen Chanock (5)
Peter Kraft (2)
1. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA
2. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
3. University of Southern California, Los Angeles, CA, USA
4. Memorial Sloan-Kettering Cancer Center, New York, NY, USA
5. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
7. Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
8. Department of General Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, Australia
9. Fred Hutchinson Cancer Research Center, Seattle, WA, USA
10. University of New Mexico, Albuquerque, NM, USA
11. Division of Cancer Care, Department of Population Health Research, Alberta Health Services, Calgary, AB, Canada
12. Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA
13. Strangeways Research Laboratory, Centre for Cancer Genetic Epidemiology (CCGE), University of Cambridge, Cambridge, UK
14. Strangeways Research Laboratory, Department of Oncology, University of Cambridge, Cambridge, UK
15. Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
16. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA
17. Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA
18. Centre for Information Based Medicine and the School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
19. Hunter Medical Research Institute, Hunter Area Pathology Service, John Hunter Hospital, Newcastle, Australia
20. Cancer Prevention Institute of California, Fremont, CA, USA
21. University of Hawaii Cancer Center, Honolulu, HI, USA
22. Department of Cancer Epidemiology and Prevention, M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland
23. Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
24. Yale University School of Public Health, New Haven, CT, USA
25. H Lee Moffitt Cancer Centre and Research Institute, Tampa, FL, USA
6. Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
26. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
27. Center for Cancer Prevention (CPO-Piemonte), Turin, Italy
28. Human Genetic Foundation (HuGeF), Turin, Italy
29. Centre for Information Based Medicine and the School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, Australia
30. University of Washington, Seattle, WA, USA
31. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China - ISSN：1432-1203
文摘
Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility.