Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus class="a-plus-plus">Penicillium sp. SCS-KFD08

详细信息    查看全文

• 作者：Fan Dong Kong ; Li Man Zhou ; Qing Yun Ma ; Sheng Zhuo Huang…
• 关键词：Marine fungus ; Metabolites ; Penicillium sp. ; Quorum sensing inhibitory activity
• 刊名：Archives of Pharmacal Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：25-31
• 全文大小：
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Pharmaceutical Society of Korea
• ISSN：1976-3786
• 卷排序：40

文摘

Three new compounds named penicitor A, aculene E and penicitor B, as well as four known compounds, were isolated from the fermentation broth of Penicillium sp. SCS-KFD08 associated with a marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mosher’s method, CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2–class="EmphasisTypeBold ">7 showed quorum sensing inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations.