High dose rate brachytherapy using molds after chemoradiotherapy for oral cavity cancer
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- 作者：Masashi Chatani (1)
Kazuki Tsuboi (1)
Masayuki Yagi (1)
Kanta Fujiwara (1)
Rika Tachimoto (1)
Hideo Yoshioka (2) - 关键词：Oral cancer ; Mold radiotherapy ; Ir high dose rate brachytherapy
- 刊名：Japanese Journal of Radiology
- 出版年：2012
- 出版时间：January 2012
- 年：2012
- 卷：30
- 期：1
- 页码：40-44
- 全文大小：272KB
- 参考文献：1. Joslin CAP, Eng C, Liversage WE, Ramsey NW. High dose-rate treatment molds by afterloading techniques. Br J Radiol. 1969;42:108-1. CrossRef
2. Miyata Y, Inoue T, Nishiyama K, Ikeda H, Ozeki S, Hayami A, et al. Remote afterloading high dose rate intracavitary radiotherapy for head and neck cancer. Nippon Acta Radiologica. 1979;39:53-.
3. Bauer M, Schulz-Wendtland R, Fritz P, Yon Fournier D. Brachytherapy of tumor recurrences in the region of the pharynx and oral cavity by means of a remote-controlled afterloading technique. Br J Radiol. 1987;60:477-0.
4. Nishimura Y, Yokose Y, Nagata Y, Okajima K, Nishida M, Hiraoka M. High-dose-rate brachytherapy using molds for oral cavity cancer: the technique and its limitations. Int J Clin Oncol. 1998;3:351-. CrossRef
5. Ariji E, Hayashi N, Kimura Y, Uchida T, Hayashi K, Nakamura T. Customized mold brachytherapy for oral carcinomas through use of high-dose-rate remote afterloading apparatus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:508-2. CrossRef
6. Yoden E, Hiratsuka J, Imajo Y, Hata T, Hosoda M. High dose rate microselectron mould radiotherapy of a widespread superficial oral cancer. Int J Oral Maxilfac Surg. 1999;28:451-. CrossRef
7. Shigematsu Y, Nishiyama K, Masaki N, Inoue T, Miyata Y, Ikeda H, et al. Treatment of carcinoma of the uterine cervix by remotely controlled afterloading intracavitary radiotherapy with high-dose rate: a comparative study with a low-dose rate system. Int J Radiat Oncol BioI Phys. 1983;9:351-.
8. AraiT Nakano T, Morita S. High-dose rate remote afterloading intracavitary radiation therapy for cancer of the uterine cervix: a 20-year experience. Cancer. 1992;69:175-0. CrossRef
9. Syndikus I, Vinall A, Rogers P, Spittle M. High dose rate microselectron moulds for Kaposi sarcoma of the palate. Radiother Oncol. 1997;42:167-0.
10. Kudo T, Ikushima H, Kudo K, Tokuyama R, Osaki K, Furuta S, et al. High-dose-rate brachytherapy for patients with maxillary gingival carcinoma using a novel customized intraoral mold technique. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:e102-. CrossRef
11. Fuchihata H, Furukawa S, Murakami S, Kubo K, Shimizutani K, Ikeda H, et al. Results of combined external irradiation and chemotherapy of bleomycin or peplomycin for squamous cell carcinomas of the lower gingiva. Int J Radiat Oncol BioI Phys. 1994;29:705-. - 作者单位：Masashi Chatani (1)
Kazuki Tsuboi (1)
Masayuki Yagi (1)
Kanta Fujiwara (1)
Rika Tachimoto (1)
Hideo Yoshioka (2)
1. Department of Radiation Oncology, Osaka Rosai Hospital, 1179-3 Nagasone-cyo, Kita-ku, Sakai, Osaka, Japan
2. Oral Surgery, Osaka Rosai Hospital, 1179-3 Nagasone-cyo, Kita-ku, Sakai, Osaka, Japan
文摘
Purpose The aim of this study was to investigate the role of the combined use of customized molds and a high dose rate (HDR) remote afterloading brachytherapy apparatus with a 192Ir microsource in the treatment of superficial oral carcinomas after chemoradiotherapy. Materials and methods Nine patients with oral squamous cell carcinoma who were treated using this combined technique were analyzed retrospectively. The primary sites of the tumors were the mouth floor, gingiva, and soft palate. For each patient, a customized mold was fabricated in which 2- afterloading catheters were placed for the 192Ir source. Three to eight fractions of 3?Gy, 5?mm below the mold surface, were given following external radiotherapy of 24-0?Gy/2?Gy combined with chemotherapy (peplomycin or taxotere). The total dose of HDR brachytherapy ranged from 9 to 24?Gy. Results The 2-year local control probability was 100% and the 2-year cause-specific survival rate was 100%. No serious complications (i.e., ulcer or bone exposure) have been observed thus far during the follow-up period of 29-20?months. Conclusion HDR brachytherapy using the mold technique after chemoradiotherapy is a safe and excellent method for selected early and superficial oral cavity cancers.