Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study
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- 作者：Abhay Raina ; Xiaoping Zhao ; Megan L. Grove ; Jan Bressler…
- 关键词：DNA methylation ; Epigenetic clock ; Epigenetic age acceleration ; White matter hyperintensities ; Cerebrovascular disease ; Aging
- 刊名：Clinical Epigenetics
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：1216KB
- 刊物主题：Human Genetics; Gene Function;
- 出版者：BioMed Central
- ISSN：1868-7083
- 卷排序：9
文摘
BackgroundCerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and dementia. We investigated the association of cerebral WMH burden on MRI with a DNA methylation-based biomarker of aging, termed DNA methylation age acceleration, which represents the deviation of the DNA methylation-predicted age from the chronologic age.