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At the frontiers of surgery: review
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  • 作者:Tahwinder Upile (1) (2) (3)
    Waseem K Jerjes (1) (2) (3) (4)
    Henricus J Sterenborg (1) (5)
    Brian J Wong (1) (6)
    Adel K El-Naggar (1) (7)
    Justus F Ilgner (8)
    Ann Sandison (1) (9)
    Max J Witjes (1) (10)
    Merrill A Biel (1) (11)
    Robert van Veen (5)
    Zaid Hamdoon (2) (3) (4)
    Ann Gillenwater (1) (12)
    Charles A Mosse (1) (13)
    Dominic J Robinson (1) (14)
    Christian S Betz (1) (15)
    Herbert Stepp (1) (16)
    Lina Bolotine (1) (17)
    Gordon McKenzie (1) (18) (2)
    Hugh Barr (1) (19)
    Zhongping Chen (1) (20)
    Kristian Berg (1) (21)
    Anil K D’Cruz (1) (22)
    Holger Sudhoff (23)
    Nicholas Stone (1) (19)
    Catherine Kendall (1) (19)
    Sheila Fisher (1) (24)
    Alexander J MacRobert (1) (13)
    Andreas Leunig (1) (15)
    Malini Olivo (1) (25)
    Rebecca Richards-Kortum (1) (26)
    Khee C Soo (1) (27)
    Vanderlei Bagnato (1) (28)
    Lin-Ping Choo-Smith (1) (29)
    Katarina Svanberg (1) (30)
    I Bing Tan (1) (31)
    Brian C Wilson (1) (32) (33)
    Herbert Wolfsen (1) (33) (34)
    Irving Bigio (1) (35)
    Arjun G Yodh (1) (36)
    Colin Hopper (1) (2) (4)
  • 刊名:Head & Neck Oncology
  • 出版年:2011
  • 出版时间:December 2011
  • 年:2011
  • 卷:3
  • 期:1
  • 全文大小:829KB
  • 参考文献:1. Hopper C, Jerjes W, Upile T: ass="a-plus-plus">Our experience with optical diagnostics of the head and neck. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O1. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O1">CrossRefa>
    2. Liu G, Kieu K, Wise FW, Wong B, Chen Z: ass="a-plus-plus">Fiber-based microendoscopic multiphoton imaging. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O35. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O35">CrossRefa>
    3. Liu L, Oh W, Bouma B, Rowe S, Tearney G: ass="a-plus-plus">Ultrahigh-resolution 3D full-field optical coherence micropscopy of the pulmonary airways ex vivo. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O10. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O10">CrossRefa>
    4. Namati E, Unglert C, Bouma B, Tearney G: ass="a-plus-plus">High-speed three-dimensional imaging of the pulmonary alveoli. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O11. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O11">CrossRefa>
    5. Unglert C, Namati E, Liu L, Yoo H, Kang D, Bouma B, Tearney G: ass="a-plus-plus">Reflectance microscopy techniques for 3D imaging of the alveolar structure. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O12. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O12">CrossRefa>
    6. Suter Melissa, Riker David, Bouma Brett, Beamis John, Guillermo Tearney: ass="a-plus-plus">Three-dimensional microscopy of the human bronchial mucosa. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O13. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O13">CrossRefa>
    7. Volgger V, Stepp H, Jerjes W, Upile T, Leunig A, Hopper C, Betz C: ass="a-plus-plus">Current Munich status concerning in-vivo optical coherence tomography for differentiating lesions of the upper aerodigestive tract. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O39. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O39">CrossRefa>
    8. Hamdoon Z, Jerjes W, McKenzie G, Jay A, Hopper C: ass="a-plus-plus">Assessment of suspicious oral lesions using optical coherence tomography. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O6. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O6">CrossRefa>
    9. Prestin S, Betz C, Kraft M: ass="a-plus-plus">Measurement of epithelial thickness within the oral cavity using optical coherence tomography (OCT). / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O42. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O42">CrossRefa>
    10. Rubinstein M, Kim J, Armstrong W, Djalilian H, Chen Z, Wong B: ass="a-plus-plus">Emerging applications for OCT in the head and neck. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O41. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O41">CrossRefa>
    11. Sterenborg HJCM, Witjes M, Visscher S, Amelink A: ass="a-plus-plus">Differential Pathlength Spectroscopy for diagnosis of head and neck cancer. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O3. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O3">CrossRefa>
    12. Pierce M, Rosbach K, Roblyer D, Muldoon T, Williams M, El-Naggar A, Gillenwater A, Richards-Kortum R: ass="a-plus-plus">Wide-field and high-resolution optical imaging for early detection of oral neoplasia. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O2. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O2">CrossRefa>
    13. Orr L, Kendall C, Hutchings J, Isabelle M, Horsnell J, Stone N: ass="a-plus-plus">Raman spectroscopy as a tool for the identification and differentiation of neoplasias contained within lymph nodes of the head and neck. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O4. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O4">CrossRefa>
    14. Rosen J, Suh H, Lee S, Aamar O, Bigio I: ass="a-plus-plus">Design, conduct and challenges of a clinical trial utilizing elastic light scattering spectroscopy in the thyroid. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O36. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O36">CrossRefa>
    15. Just T, Lankenau E, Hüttmann G, Pau H: ass="a-plus-plus">An optical coherence tomography study for imaging the round window niche and the promontorium tympani. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O5. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O5">CrossRefa>
    16. Hüttmann G, Probst J, Just T, Pau H, Oelckers S, Hillmann D, Koch P, Lankenau E: ass="a-plus-plus">Real-time volumetric optical coherence tomography OCT imaging with a surgical microscope. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O8. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O8">CrossRefa>
    17. Wenzel G, Lim H, Zhang K, Balster S, Massow O, Lubatschowski H, Reuter G, Lenarz T: ass="a-plus-plus">Laser hearing aids. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O31. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O31">CrossRefa>
    18. Wisweh H, Mateu LM, Kraft M, Krüger A, Lubatschowski H: ass="a-plus-plus">Automatic segmentation of clinical OCT images for the determination of epithelial thickness changes in laryngeal lesions. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O9. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O9">CrossRefa>
    19. Choo-Smith L, Hewko M, Sowa M: ass="a-plus-plus">Towards early dental caries detection with OCT and polarized Raman spectroscopy. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O43. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O43">CrossRefa>
    20. Hamdoon Z, Jerjes W, McKenzie G, Jay A, Hopper C: ass="a-plus-plus">Assessment of tumour resection margins using optical coherence tomography. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O7. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O7">CrossRefa>
    21. Chen H, Yu L, Manuel C, Wong BJ: ass="a-plus-plus">Using optical coherence tomography to monitor effects of electromechanical reshaping in septal cartilage. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O19. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O19">CrossRefa>
    22. Sobol E, Sviridov A, Vorobieva N, Svistushkin V: ass="a-plus-plus">Feedback controlled laser system for safe and efficient reshaping of nasal cartilage. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O17. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O17">CrossRefa>
    23. Foulad A, Manuel C, Kim J, Wong BJF: ass="a-plus-plus">Numerical analysis of costal cartilage warping after laser modification. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O22. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O22">CrossRefa>
    24. Stepp H: ass="a-plus-plus">Endoscopic ICG perfusion imaging for flap transplants: technical development. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O14. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O14">CrossRefa>
    25. Betz C: ass="a-plus-plus">Endoscopic ICG perfusion imaging for flap transplants: clinical results. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O15. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O15">CrossRefa>
    26. Larson M, Sooklal V, McClure J, Hooper L, Sieber J: ass="a-plus-plus">A laser device for fusion of nasal mucosa. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O23. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O23">CrossRefa>
    27. Fishman A, Moreno L, Rivera A, Richter C: ass="a-plus-plus">Lasers, a tool for soft cochleostomies. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O38. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O38">CrossRefa>
    28. Kaylie D, Miller J: ass="a-plus-plus">CO ass="a-plus-plus"> ass="a-plus-plus">2 ass="a-plus-plus">laser myringoplasty using handheld waveguide. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O32. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O32">CrossRefa>
    29. Armstrong WB, Rubinstein M: ass="a-plus-plus">CO ass="a-plus-plus"> ass="a-plus-plus">2 ass="a-plus-plus">Laser Transoral Laser Microsurgery of Head and Neck Cancer: Lessons Learned over Ten Years. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O37. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O37">CrossRefa>
    30. Jerjes W, Upile T, Hamdoon Z, Hopper C: ass="a-plus-plus">CO ass="a-plus-plus"> ass="a-plus-plus">2 ass="a-plus-plus">laser ablation of oropharyngeal dysplasia. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O34. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O34">CrossRefa>
    31. Jerjes W, Upile T, Hamdoon Z, Hopper C: ass="a-plus-plus">The use of CO2 laser in tumour resection of the oropharyngeal region. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O33. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O33">CrossRefa>
    32. Ben-Yakar A, Hoy C, Everett WN, Kobler J: ass="a-plus-plus">Toward endoscopic ultrafast laser microsurgery of vocal folds. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O29. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O29">CrossRefa>
    33. van Veen RLP, Robinson DJ, Sterenborg HJCM, Aans JB, Tan IB, Hamming Vrieze O, Hoebers F, Witjes MJH, Levendag PC: ass="a-plus-plus">Treatment planning for Interstitial Photodynamic Therapy for head and neck cancer. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O45. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O45">CrossRefa>
    34. Kanick S, Karakullukcu B, van Veen R, Sterenborg H, Tan IB, Witjes M, Amelink A, Robinson D: ass="a-plus-plus">In vivo monitoring of Foscan-mediated photodynamic therapy in clinical head and neck procedures using optical spectroscopy. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O16. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O16">CrossRefa>
    35. de Visscher S, Witjes M, Kascáková S, Robinson D, Sterenborg H, Roodenburg J, Amelink A: ass="a-plus-plus">Non-invasive measurement of photosensitiser concentration using fluorescence differential path-length spectroscopy: validation for different liposomal formulations of m-THPC: Foscan, Foslip and Fospeg. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O46. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O46">CrossRefa>
    36. Osher J, Jerjes W, Upile T, Hamdoon Z, Nhembe F, Bhandari R, Mackay S, Shah P, Mosse CA, Morley S, Hopper C: ass="a-plus-plus">Ultrasound-guided interstitial photodynamic therapy for deeply seated pathologies: assessment of outcome. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O26. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O26">CrossRefa>
    37. Hopper C, Jerjes W, Hamdoon Z, Upile T: ass="a-plus-plus">The role of photodynamic therapy in the management of oral dysplasia. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O24. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O24">CrossRefa>
    38. Shafirstein G, B?umler W, Sigel E, Fan C, Berry K, Vural E, Stack BC, Suen JY: ass="a-plus-plus">Utilizing 5-Aminolevulinic Acid and Pulsed Dye Laser for Photodynamic Therapy of Oral Leukoplakia - Pilot study. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O40. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O40">CrossRefa>
    39. Biel M: ass="a-plus-plus">Photodynamic therapy of laryngeal cancers. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O25. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O25">CrossRefa>
    40. Jerjes W, Upile T, Hamdoon Z, Nhembe F, Bhandari R, Mackay S, Mosse CA, Morley S, Hopper C: ass="a-plus-plus">Photodynamic therapy as the "last hope" for tongue-based carcinoma. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O27. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O27">CrossRefa>
    41. Jerjes W, Mosse C, Hamdoon Z, Carnell D, Berg K, H?gset A, Hopper C: ass="a-plus-plus">Photochemical internalization. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O44. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O44">CrossRefa>
    42. Rhee C, Chang S, Chung P, Jung J, Ahn J, Suh M: ass="a-plus-plus">The effect of PDT on H. influenzae biofilm in vivo. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O28. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O28">CrossRefa>
    43. Ilgner JF, Biedron S, Fadeeva E, Cichkov B, Klee D, Loos A, Sowa-Soehle E, Westhofen M: ass="a-plus-plus">Femtosecond laser microstructuring and bioactive nanocoating of titanium surfaces in relation to chondrocyte growth. / Head & Neck Oncology 2010,ass="a-plus-plus">2(Suppl 1)ass="a-plus-plus">:O30. <a class="external" href="http://dx.doi.org/10.1186/1758-3284-2-S1-O30">CrossRefa>
  • 作者单位:Tahwinder Upile (1) (2) (3)
    Waseem K Jerjes (1) (2) (3) (4)
    Henricus J Sterenborg (1) (5)
    Brian J Wong (1) (6)
    Adel K El-Naggar (1) (7)
    Justus F Ilgner (8)
    Ann Sandison (1) (9)
    Max J Witjes (1) (10)
    Merrill A Biel (1) (11)
    Robert van Veen (5)
    Zaid Hamdoon (2) (3) (4)
    Ann Gillenwater (1) (12)
    Charles A Mosse (1) (13)
    Dominic J Robinson (1) (14)
    Christian S Betz (1) (15)
    Herbert Stepp (1) (16)
    Lina Bolotine (1) (17)
    Gordon McKenzie (1) (18) (2)
    Hugh Barr (1) (19)
    Zhongping Chen (1) (20)
    Kristian Berg (1) (21)
    Anil K D’Cruz (1) (22)
    Holger Sudhoff (23)
    Nicholas Stone (1) (19)
    Catherine Kendall (1) (19)
    Sheila Fisher (1) (24)
    Alexander J MacRobert (1) (13)
    Andreas Leunig (1) (15)
    Malini Olivo (1) (25)
    Rebecca Richards-Kortum (1) (26)
    Khee C Soo (1) (27)
    Vanderlei Bagnato (1) (28)
    Lin-Ping Choo-Smith (1) (29)
    Katarina Svanberg (1) (30)
    I Bing Tan (1) (31)
    Brian C Wilson (1) (32) (33)
    Herbert Wolfsen (1) (33) (34)
    Irving Bigio (1) (35)
    Arjun G Yodh (1) (36)
    Colin Hopper (1) (2) (4)

    1. The ″Head and Neck Optical Diagnostics Society-Council, Head & Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    2. Department of Surgery, University College London Medical School, London, UK
    3. Department of Otolaryngology/Head and Neck Surgery, Barnet and Chase Farm Hospitals NHS Trust, London, UK
    4. Unit of Oral & Maxillofacial Surgery, Division of Maxillofacial, Diagnostic, Medical and Surgical Sciences, UCL Eastman Dental Institute, London, UK
    5. Center for Optical Diagnostics and Therapy, Erasmus University Medical Center, Rotterdam, the Netherlands
    6. The Beckman Laser Institute and Medical Clinic, The University of California Irvine, Irvine, CA, USA
    7. Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    8. Department of Otorhinolaryngology, Plastic Head and Neck Surgery, Aachen University Hospital, RWTH Aachen, Germany
    9. Department of Histopathology, Imperial College and The Hammersmith Hospitals, London, UK
    10. Department of Oral & Maxilofacial Surgery, University Medical Center Groningen, Groningen, the Netherlands
    11. Virginia Piper Cancer Institute-Abbott Northwestern Hospital, Minnesota, USA
    12. Department of Head and Neck Surgery, Division of Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, Germany
    13. National Medical Laser Centre, University College London, London, UK
    14. Center for Optical Diagnostics and Therapy, Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands
    15. Department of Otorhinolaryngology, Head & Neck Surgery, Ludwig Maximilian University, Munich, Germany
    16. LIFE Center, University Clinic Munich, Munich, Germany
    17. Research Centre for Automatic Control (CRAN), Nancy-University, UMR CNRS, Nancy, France
    18. Michelson Diagnostics, 11A Grays Farm Production Village, Grays Farm Road, Orpington, Kent, BR5 3BD, UK
    19. Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK
    20. Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, USA
    21. Dept. of Radiation Biology, The Norwegian Radium Hospital, Montebello, Norway
    22. Department of Oral & Maxillofacial Surgery, Tata Memorial Hospital, Mumbai, India
    23. Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum Bielefeld, Bielefeld, Germany
    24. Department of Oral & Maxillofacial Surgery, Leeds Dental Institute, Leeds, UK
    25. National University of Ireland, Galway, Ireland
    26. Department of Bioengineering, Rice University, Houston, USA
    27. National Cancer Centre, Singapore, 169610, Singapore
    28. University of Sao Paulo, Sao Carlos, SP, Brazil
    29. National Research Council Canada-Institute for Biodiagnostics, Winnipeg, Manitoba, Canada
    30. Division of Oncology, Lund University Hospital, Lund, Sweden
    31. Department of Head & Neck Oncology & Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
    32. Division of BioPhysics and BioImaging, Ontario Cancer Institute, Ontario, Canada
    33. Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada
    34. Division of Gastroenterology and Hepatology, Mayo Clinic, Florida, USA
    35. Department of Biomedical Engineering, Electrical & Computer Engineering, Physics, Boston University, Boston, Canada
    36. Physics and Astronomy, University of Pennsylvania, Philadelphia, USA
文摘
The complete surgical removal of disease is a desirable outcome particularly in oncology. Unfortunately much disease is microscopic and difficult to detect causing a liability to recurrence and worsened overall prognosis with attendant costs in terms of morbidity and mortality. It is hoped that by advances in optical diagnostic technology we could better define our surgical margin and so increase the rate of truly negative margins on the one hand and on the other hand to take out only the necessary amount of tissue and leave more unaffected non-diseased areas so preserving function of vital structures. The task has not been easy but progress is being made as exemplified by the presentations at the 2nd Scientific Meeting of the Head and Neck Optical Diagnostics Society (HNODS) in San Francisco in January 2010. We review the salient advances in the field and propose further directions of investigation.

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