Comorbid Moderate–Severe Depressive Symptoms and their Association with Quality of Life in Chinese Patients with Schizophrenia Treated in Primary Care

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• 作者：Cai-Lan Hou ; Xin-Rong Ma ; Mei-Ying Cai ; Yan Li ; Yu Zang…
• 关键词：Schizophrenia ; Depressive symptoms ; Community ; dwelling ; Primary care ; China
• 刊名：Community Mental Health Journal
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：52
• 期：8
• 页码：921-926
• 全文大小：597 KB
• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Psychology
  Psychiatry
  Health Psychology
  Personality and Social Psychology
  Community and Environmental Psychology
  Public Health
  
• 出版者：Springer Netherlands
• ISSN：1573-2789
• 卷排序：52

文摘

This study described the prevalence and correlates of comorbid moderate–severe depressive symptoms (comorbid depression thereafter) and their association with quality of life (QOL) in schizophrenia patients treated in primary care. 623 schizophrenia patients were enrolled. Patients’ socio-demographic and clinical characteristics including comorbid depression [defined as a total score of 18 or above on the Montgomery–Asberg Depression Rating Scale (MADRS)] were recorded. Depressive symptoms (defined as a total score of 9 or above on the MADRS) were present in 54.1 % of patients, while 17.7 % had comorbid depression. Analysis of covariance revealed that comorbid depression was significantly associated with lower mental QOL. Multiple logistic regression analysis revealed that more severe positive and negative symptoms, anxiety symptoms, use of first-generation antipsychotics and antidepressants, were independently associated with comorbid depression. Given the negative association between comorbid depression and QOL, attempts to address comorbid depression in schizophrenia patients treated in primary care should be made.