Decreased PD-1/PD-L1 Expression Is Associated with the Reduction in Mucosal Immunoglobulin A in Mice with Intestinal Ischemia Reperfusion

详细信息    查看全文

• 作者：Xu-Yu Zhang ; Zi-Meng Liu ; Hu-fei Zhang ; Yun-Sheng Li…
• 关键词：Intestinal mucosa ; Reperfusion injury ; Programmed cell death 1 receptor ; Immunoglobulin A ; Immunoglobulin class switching
• 刊名：Digestive Diseases and Sciences
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：60
• 期：9
• 页码：2662-2669
• 全文大小：2,132 KB
• 参考文献：1.Mallick IH, Yang W, Winslet MC, et al. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci. 2004;49:1359鈥?377.CrossRef PubMed
  2.Feinman R, Deitch EA, Watkins AC, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2010;299:G833鈥?43.PubMed Central CrossRef PubMed
  3.Martin B. Prevention of gastrointestinal complications in the critically ill patient. AACN Adv Crit Care. 2007;18:158鈥?66.CrossRef PubMed
  4.Zhang XY, Liu ZM, Wen SH, et al. Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats. Anesthesiology. 2012;116:1035鈥?046.CrossRef PubMed
  5.Liu KX, Li YS, Huang WQ, et al. Immediate postconditioning during reperfusion attenuates intestinal injury. Intensive Care Med. 2009;35:933鈥?42.CrossRef PubMed
  6.Li H, Wu GH, Chen J. Effect of glucagon-like peptide 2 on the intestinal mucosal immunity and correlative cytokines in mice with gut ischemia/reperfusion injury. Zhonghua Wei Chang Wai Ke Za Zhi. 2006;9:67鈥?0.PubMed
  7.Fukatsu K, Sakamoto S, Hara E, et al. Gut ischemia-reperfusion affects gut mucosal immunity: a possible mechanism for infectious complications after severe surgical insults. Crit Care Med. 2006;34:182鈥?87.CrossRef PubMed
  8.Yoshiya K, Lapchak PH, Thai TH, et al. Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1020鈥?030.CrossRef PubMed
  9.Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12:821鈥?32.CrossRef PubMed
  10.Fagarasan S, Kawamoto S, Kanagawa O, et al. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu Rev Immunol. 2010;28:243鈥?73.CrossRef PubMed
  11.Agata Y, Kawasaki A, Nishimura H, et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol. 1996;8:765鈥?72.CrossRef PubMed
  12.Sharpe AH, Wherry EJ, Ahmed R, et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007;8:239鈥?45.CrossRef PubMed
  13.Schreiner B, Mitsdoerffer M, Kieseier BC, et al. Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PDL1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J Neuroimmunol. 2004;155:172鈥?82.CrossRef PubMed
  14.Esch KJ, Juelsgaard R, Martinez PA, et al. Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function. J Immunol. 2013;191:5542鈥?550.PubMed Central CrossRef PubMed
  15.Simone R, Piatti G, Saverino D. The inhibitory co-receptors: a way to save from anergy the HIV-specific T cells. Curr HIV Res. 2009;7:266鈥?72.CrossRef PubMed
  16.Kawamoto S, Tran TH, Maruya M, et al. The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science. 2012;336:485鈥?89.CrossRef PubMed
  17.Chiu CJ, McArdle AH, Brown R, et al. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 1970;101:478鈥?83.CrossRef PubMed
  18.Seo GY, Youn J, Kim PH. IL-21 ensures TGF-beta 1-induced IgA isotype expression in mouse Peyer鈥檚 patches. J Leukoc Biol. 2009;85:744鈥?50.CrossRef PubMed
  19.God铆nez-Victoria M, Drago-Serrano ME, Reyna-Garfias H, et al. Effects on secretory IgA levels in small intestine of mice that underwent moderate exercise training followed by a bout of strenuous swimming exercise. Brain Behav Immun. 2012;26:1300鈥?309.CrossRef PubMed
  20.Duraiswamy J, Kaluza KM, Freeman GJ, et al. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 2013;73:3591鈥?603.PubMed Central CrossRef PubMed
  21.Belai EB, de Oliveira CE, Gasparoto TH, et al. PD-1 blockage delays murine squamous cell carcinoma development. Carcinogenesis. 2014;35:424鈥?31.CrossRef PubMed
  22.Zhang Y, Zhou Y, Lou J, et al. PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction. Crit Care. 2010;14:R220.PubMed Central CrossRef PubMed
  23.Guignant C, Lepape A, Huang X, et al. Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit Care. 2011;15:R99.PubMed Central CrossRef PubMed
  24.Ji H, Shen X, Gao F, et al. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 2010;52:1380鈥?389.PubMed Central CrossRef PubMed
  25.Jaworska K, Ratajczak J, Huang L, et al. Both PD-1 ligands protect the kidney from ischemia reperfusion injury. J Immunol. 2015;194:325鈥?33.CrossRef PubMed
  26.Stavnezer J, Kang J. The surprising discovery that TGF beta specifically induces the IgA class switch. J Immunol. 2009;182:5鈥?.CrossRef PubMed
  27.Carter L, Fouser LA, Jussif J, Fitz L, et al. PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol. 2002;32:634鈥?43.CrossRef PubMed
  28.Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192:1027鈥?034.PubMed Central CrossRef PubMed
  29.Fagarasan S, Honjo T. Regulation of IgA synthesis at mucosal surfaces. Curr Opin Immunol. 2004;16:277鈥?83.CrossRef PubMed
  30.Kato LM, Kawamoto S, Maruya M, et al. Gut TFH and IgA: key players for regulation of bacterial communities and immune homeostasis. Immunol Cell Biol. 2014;92:49鈥?6.CrossRef PubMed
  31.Suzuki K, Meek B, Dous Y, et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci USA. 2004;101:1981鈥?986.PubMed Central CrossRef PubMed
  32.Fagarasan S, Muramatsu M, Suzuki K, et al. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science. 2002;298:1424鈥?427.CrossRef PubMed
  33.Phalipon A. Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells. Immunity. 2003;18:739鈥?49.CrossRef PubMed
  34.Aytekin C, Tuygun N, Gokce S, et al. Selective IgA deficiency: clinical and laboratory features of 118 children in Turkey. J Clin Immunol. 2012;32:961鈥?66.CrossRef PubMed
  35.Wang N, Shen N, Vyse TJ, et al. Selective IgA deficiency in autoimmune diseases. Mol Med. 2011;17:1383鈥?396.PubMed Central PubMed
  36.Strugnell RA, Wijburg OL. The role of secretory antibodies in infection immunity. Nat Rev Microbiol. 2010;8:656鈥?67.CrossRef PubMed
  
• 作者单位：Xu-Yu Zhang (1)
  Zi-Meng Liu (2)
  Hu-fei Zhang (1)
  Yun-Sheng Li (1)
  Shi-Hong Wen (1)
  Jian-Tong Shen (1)
  Ke-Xuan Liu (1)
  
  1. Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou, 510080, China
  2. Surgical Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

Background Intestinal ischemia/reperfusion (I/R) disrupts intestinal mucosal integrity and immunoglobulin A (IgA) generation. It has recently been shown that the programmed cell death-1 receptor (PD-1) plays a crucial role in regulating intestinal secreted IgA (sIgA).