Amazing structure of respirasome: unveiling the secrets of cell respiration
详细信息 查看全文
- 作者：Runyu Guo ; Jinke Gu ; Meng Wu ; Maojun Yang
- 关键词：respirasome structure ; supercomplexes organization ; cellular respiration ; respiratory complexes ; megacomplex
- 刊名：Protein & Cell
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：7
- 期：12
- 页码：854-865
- 全文大小：2495KB
- 刊物主题：Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;
- 出版者：Higher Education Press
- ISSN：1674-8018
- 卷排序：7
文摘
Respirasome, a huge molecular machine that carries out cellular respiration, has gained growing attention since its discovery, because respiration is the most indispensable biological process in almost all living creatures. The concept of respirasome has renewed our understanding of the respiratory chain organization, and most recently, the structure of respirasome solved by Yang’s group from Tsinghua University (Gu et al. Nature 237(7622):639–643, 2016) firstly presented the detailed interactions within this huge molecular machine, and provided important information for drug design and screening. However, the study of cellular respiration went through a long history. Here, we briefly showed the detoured history of respiratory chain investigation, and then described the amazing structure of respirasome.