A phase I dose escalation and pharmacokinetic study of vatalanib (PTK787/ZK 222584) in combination with paclitaxel in patients with advanced solid tumors
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- 作者：E. Gabriela Chiorean ; Srikar Malireddy ; Anne E. Younger ; David R. Jones ; Mary-Jane Waddell ; Melissa I. Sloop ; Menggang Yu ; Stephen D. Hall ; Bryan Schneider and Christopher J. Sweeney
- 关键词：Paclitaxel ; Phase I ; PTK/ZK ; VEGFR
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2010
- 出版时间：August, 2010
- 年：2010
- 卷：66
- 期：3
- 页码：441-448
- 全文大小：233.3 KB
文摘
Purpose To define the maximum-tolerated dose (MTD) for weekly paclitaxel administered in combination with daily vatalanib (PTK787/ZK 222584, PTK/ZK) and assess for a drug–drug interaction.