Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys
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- 作者：Jin Yang ; Yaqi An ; Haiyan Wu ; Miao Liu ; Weiguang Wang ; Xue Du…
- 关键词：Isodon phyllostachys ; diterpenoid ; ent ; kaurane ; ent ; abietane
- 刊名：SCIENCE CHINA Chemistry
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：59
- 期：9
- 页码：1211-1215
- 全文大小：566 KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Chinese Library of Science
Chemistry - 出版者：Science China Press, co-published with Springer
- ISSN：1869-1870
- 卷排序：59
文摘
Four new diterpenoids, phyllostachysins I–L (1–4), along with a known one, hebeiabinin B (5), were isolated from the aerial parts of Isodon phyllostachys (I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.