Automatic gain control in mass spectrometry using a jet disrupter electrode in an electrodynamic ion funnel
详细信息 查看全文
- 作者：Jason S. Page (1)
Bogdan Bogdanov (1)
Andrey N. Vilkov (1)
David C. Prior (1)
Michael A. Buschbach (1)
Keqi Tang (1)
Richard D. Smith (1) - 刊名：Journal of The American Society for Mass Spectrometry
- 出版年：2005
- 出版时间：February 2005
- 年：2005
- 卷：16
- 期：2
- 页码：244-253
- 全文大小：432KB
- 参考文献：1. Patel, P. H.; Suzuki, M.; Adman, E.; Shinkai, A.; Loeb, L. A. Prokaryotic DNA Polymerase I: Evolution, Structure, and 鈥淏ase Flipping鈥?Mechanism for Nucleotide Selection. / J. Mol. Biol. 2001, / 308, 823鈥?37. CrossRef
2. Pieper, R.; Gatlin, C. L.; Makusky, A. J.; Russo, P. S.; Schatz, C. R.; Miller, S. S.; Su, Q.; McGrath, A. M.; Estock, M. A.; Parmar, P. P.; Zhao, M.; Huang, S. T.; Zhou, J.; Wang, F.; Esquer-Blasco, R.; Anderson, N. L.; Taylor, J.; Steiner, S. Identification and Quantification of N-linked Glycoproteins using Hydrazide Chemistry, Stable-Isotope Labeling, and Mass Spectrometry. / Proteomics 2003, / 3, 422鈥?32. CrossRef
3. Gygi, S. P.; Rist, B.; Gerber, S. A.; Turecek, F.; Gelb, M. H.; Aebersold, R. Quantitative Analysis of Complex Protein Mixture using Isotope-Coded Affinity Tags. / Nat. Biotechnol. 1999, / 17, 994鈥?99. CrossRef
4. Pieper, R.; Su, Q.; Gatlin, C. L.; Huang, S.-T.; Anderson, N. L.; Steiner, S. Multi-Component Immunoaffinity Subtraction Chromatography: An Innovative Step Towards a Comprehensive Survey of the Human Plasma Proteome. / Proteomics 2003, / 3, 422鈥?32. CrossRef
5. Link, A. J. Multidimensional Peptide Separations in Proteomics. / Trends Biotechnol. 2002, / 20, S8-S13. CrossRef
6. Wu, S.-L.; Amato, H.; Biringer, R.; Choudhary, G.; Shieh, P.; Hancock, W. S. Targeted Proteomics of Low-Level Proteins in Human Plasma by LC/MSn: Using Human Growth Hormone as a Model System. / J. Proteome Res. 2002, / 1, 459鈥?65. CrossRef
7. Harkewicz, R.; Belov, M. E.; Anderson, G. A.; Pasa-Tolic, L.; Masselon, C. D.; Prior, D. C.; Udseth, H. R.; Smith, R. D. ESI-FTICR Mass Spectrometry Employing Data-Dependant External Ion Selection and Accumulation. / J. Am. Soc. Mass Spectrom. 2002, / 13, 144鈥?54. CrossRef
8. Belov, M. E.; Zhang, R.; Strittmatter, E. F.; Prior, D. C.; Tang, K.; Smith, R. D. Automated Gain Control and Internal Calibration with External Ion Accumulation Capillary Liquid Chromatography-Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance. / Anal. Chem. 2003, / 75, 4195鈥?205. CrossRef
9. Schwartz, J. C.; Zhou, X.-G.; Bier, M. E. Method and apparatus of increasing dynamic range and sensitivity of a mass spectrometer. / US Patent 5,572,022; 1996.
10. Belov, M. E.; Rakov, V. S.; Nikolaev, E. N.; Goshe, M. B.; Anderson, G. A.; Smith, R. D. Initial Implementation of External Accumulation Liquid Chromatography/Electrospray Ionization Fourier Transform Ion Cyclotron Resonance with Automated Gain Control. / Rapid Commun. Mass Spectrom. 2003, / 17, 627鈥?36. CrossRef
11. Senko, M.; Zabrouskov, V.; Lange, O.; Wieghaus, A.; Horning, S. LC/MS with External Calibration Mass Accuracies Approaching 100 ppb. / Proceedings of the 52nd ASMS Conference on Mass Spectrometry; Nashville, TN, May 2004.
12. Taylor, P. K.; Amster, I. J. Space Charge Effects on Mass Accuracy for Multiply Charged Ions in ESI-FTICR. / Int. J. Mass Spectrom. 2003, / 222, 351鈥?61. CrossRef
13. Masselon, C.; Tolmachev, A. V.; Anderson, G. A.; Harkewicz, R.; Smith, R. D. Mass Measurement Errors Caused by 鈥淟ocal鈥?Frequency Perturbations in FTICR Mass Spectrometry. / J. Am. Soc. Mass Spectrom. 2002, / 13, 99鈥?06. CrossRef
14. Easterling, M. L.; Mize, T. H.; Amster, I. J. Routine Parts-per-Million Mass Accuracy for High-Mass Ions: Space-Charge Effects in MALDI FT-ICR. / Anal. Chem. 1999, / 71, 624鈥?32. CrossRef
15. Vedel, F.; Andre, J. Influence of Space Charge on the Computed Statistical Properties of Stored Ions Cooled by a Buffer Gas in a Quadrupole RF Trap. / Phys. Rev. A 1984, / 29, 2098鈥?101. CrossRef
16. Cox, K. A.; Cleven, C. D.; Cooks, R. G. Mass Shifts and Local Space Charge Effects Observed in the Quadrupole Ion Trap at Higher Resolution. / Int. J. Mass Spectrom. Ion Processes 1995, / 144, 47鈥?5. CrossRef
17. Mathurin, J. C.; Gregoire, S.; Brunot, A.; Tabet, J. C.; March, R. E.; Catinella, S.; Traldi, P. Investigation of Space Charge Interactions which Arise During Simultaneous Confinement of Positive and Negative Ions in an Ion Trap Mass Spectrometer. / J. Mass Spectrom. 1997, / 32, 829鈥?37. CrossRef
18. Alheit, R.; Kleineidam, S.; Vedel, F.; Vedel, M.; Werth, G. Higher Order Non-Linear Resonances in a Paul Trap. / Int. J. Mass Spectrom. Ion Processes 1996, / 154, 155鈥?69. CrossRef
19. Cleven, C. D.; Cox, K. A.; Cooks, R. G.; Bier, M. E. Mass Shifts Due to Ion-Ion Interactions in a Quadrupole Ion-Trap Mass-Spectrometer. / Rapid Commun. Mass Spectrom. 1994, / 8, 451鈥?54. CrossRef
20. Takach, E. J.; Hines, W. M.; Patterson, D. H.; Juhasz, P.; Falick, A. M.; Vestal, M. L.; Martin, S. A. Accurate Mass Measurements using MALDI-TOF with Delayed Extraction. / J. Protein Chem. 1997, / 16, 363鈥?69. CrossRef
21. Dehmelt, H. G. Radiofrequency Spectroscopy of Stored Ions. I: Storage. / Adv. Atom. Mol. Phys. 1967, / 3, 53鈥?2. CrossRef
22. Belov, M. E.; Nikolaev, E. N.; Harkewicz, R.; Masselon, C. D.; Alving, K.; Smith, R. D. Ion Discrimination During Ion Accumulation in a Quadrupole Interface External to a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer. / Int. J. Mass. Spectrom. 2001, / 208, 205鈥?25. CrossRef
23. Sannes-Lowery, K.; Griffey, R. H.; Kruppa, G. H.; Speir, J. P.; Hofstadler, S. A. Multipole Storage Assisted Dissociation, a Novel in-Source Dissociation Technique for Electrospray Ionization Generated Ions. / Rapid Commun. Mass Spectrom. 1998, / 12, 1957鈥?961. CrossRef
24. Hakansson, K.; Axelsson, J.; Palmblad, M.; Hakansson, P. Mechanistic Studies of Multipole Storage Assisted Dissociation. / J. Am. Soc. Mass Spectrom. 2000, / 11, 210鈥?15. CrossRef
25. Sannes-Lowery, K. A.; Hofstadler, S. A. Characterization of Multipole Storage Assisted Dissociation: Implications for Electrospray Ionization Mass Spectrometry Characterization of Biomolecules. / J. Am. Soc. Mass Spectrom. 2000, / 11, 1鈥?. CrossRef
26. Tang, K.; Tolmachev, A. V.; Nikolaev, E.; Zhang, R.; Belov, M. E.; Udseth, H. R.; Smith, R. D. Independent Control of Ion Transmission in a Jet Disrupter Dual-Channel Ion Funnel Electrospray Ionization MS Interface. / Anal. Chem. 2002, / 74, 5431鈥?437. CrossRef
27. Taeman, K.; Tolmachev, A. V.; Harkewicz, R.; Prior, D. C.; Anderson, G.; Udseth, H. R.; Smith, R. D.; Bailey, T. H.; Rakov, S.; Futrell, J. H. Design and Implementation of a New Electrodynamic Ion Funnel. / Anal. Chem. 2000, / 72, 2247鈥?255. CrossRef
28. Shaffer, S. A.; Tang, K.; Anderson, G. A.; Prior, D. C.; Udseth, H. R.; Smith, R. D. A Novel Ion Funnel for Focusing Ions at Elevated Pressure Using Electrospray Ionization Mass Spectrometry. / Rapid Commun. Mass Spectrom. 1997, / 11, 1813鈥?817. CrossRef
29. Shaffer, S. A.; Prior, D. C.; Anderson, G. A.; Udseth, H. R.; Smith, R. D. An Ion Funnel Interface for Improved Ion Focusing and Sensitivity Using Electrospray Ionization Mass Spectrometry. / Anal. Chem. 1998, / 70, 4111鈥?119. CrossRef
30. Shaffer, S. A.; Tolmachev, A.; Prior, D. C.; Anderson, G. A.; Udseth, H. R.; Smith, R. D. Characterization of an Improved Electrodynamic Ion Funnel Interface for Electrospray Ionization Mass Spectrometry. / Anal. Chem. 1999, / 71, 2957鈥?964. CrossRef
31. Kim, T.; Tang, K.; Udseth, H. R.; Smith, R. D. A Multicapillary Inlet Jet Disruption Electrodynamic Ion Funnel Interface for Improved Sensitivity Using Atmospheric Pressure Ion Sources. / Anal. Chem. 2001, / 73, 4162鈥?170. CrossRef
32. Winger, B.; Light-Wahl, K.; Ogorzalek-Loo, R.; Udseth, H. R.; Smith, R. D. Observation and Implications of High Mass-to-Charge Ratio Ions from Electrospray Ionization Mass Spectrometry. / J. Am. Soc. Mass Spectrom. 1993, / 4, 536鈥?45. CrossRef - 作者单位：Jason S. Page (1)
Bogdan Bogdanov (1)
Andrey N. Vilkov (1)
David C. Prior (1)
Michael A. Buschbach (1)
Keqi Tang (1)
Richard D. Smith (1)
1. Biological Systems Analysis and Mass Spectrometry, Pacific Northwest National Laboratory, 3335 Q Ave. (K8-98), P.O. Box 999, 99352, Richland, WA, USA
文摘
We report on the use of a jet disrupter electrode in an electrodynamic ion funnel as an electronic valve to regulate the intensity of the ion beam transmitted through the interface of a mass spectrometer in order to perform automatic gain control (AGC). The ion flux is determined by either directly detecting the ion current on the conductance limiting orifice of the ion funnel or using a short mass spectrometry acquisition. Based upon the ion flux intensity, the voltage of the jet disrupter is adjusted to alter the transmission efficiency of the ion funnel to provide a desired ion population to the mass analyzer. Ion beam regulation by an ion funnel is shown to provide control to within a few percent of a targeted ion intensity or abundance. The utility of ion funnel AGC was evaluated using a protein tryptic digest analyzed with liquid chromatography Fourier transform ion cyclotron resonance (LC-FTICR) mass spectrometry. The ion population in the ICR cell was accurately controlled to selected levels, which improved data quality and provided better mass measurement accuracy.