Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium

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• 作者：Joanne W. Elena (1)
  Emily Steplowski (2)
  Kai Yu (3)
  Patricia Hartge (3)
  Geoffrey S. Tobias (3)
  Michelle J. Brotzman (4)
  Stephen J. Chanock (3) (45)
  Rachael Z. Stolzenberg-Solomon (3)
  Alan A. Arslan (5) (6) (7)
  H. Bas Bueno-de-Mesquita (8) (9)
  Kathy Helzlsouer (10)
  Eric J. Jacobs (13)
  Andrea LaCroix (14)
  Gloria Petersen (15)
  Wei Zheng (16)
  Demetrius Albanes (3)
  Naomi E. Allen (17)
  Laufey Amundadottir (3) (45)
  Ying Bao (18)
  Heiner Boeing (19)
  Marie-Christine Boutron-Ruault (20)
  Julie E. Buring (21) (22)
  J. Michael Gaziano (23) (24)
  Edward L. Giovannucci (25) (26) (27)
  Eric J. Duell (28)
  G?ran Hallmans (29)
  Barbara V. Howard (30)
  David J. Hunter (25) (26)
  Amy Hutchinson (31) (45)
  Kevin B. Jacobs (3)
  Charles Kooperberg (14)
  Peter Kraft (25)
  Julie B. Mendelsohn (3)
  Dominique S. Michaud (32) (33)
  Domenico Palli (34)
  Lawrence S. Phillips (35) (36)
  Kim Overvad (37)
  Alpa V. Patel (13)
  Leah Sansbury (1) (38)
  Xiao-Ou Shu (16)
  Michael S. Simon (39)
  Nadia Slimani (40)
  Dimitrios Trichopoulos (25) (41)
  Kala Visvanathan (11) (12)
  Jarmo Virtamo (42)
  Brian M. Wolpin (18) (43)
  Anne Zeleniuch-Jacquotte (6) (7)
  Charles S. Fuchs (18) (43)
  Robert N. Hoover (3)
  Myron Gross (44)
  
• 关键词：Diabetes ; Risk factor ; Cohort consortium ; Pancreatic cancer
• 刊名：Cancer Causes and Control
• 出版年：2013
• 出版时间：January 2013
• 年：2013
• 卷：24
• 期：1
• 页码：13-25
• 全文大小：269KB
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• 作者单位：Joanne W. Elena (1)
  Emily Steplowski (2)
  Kai Yu (3)
  Patricia Hartge (3)
  Geoffrey S. Tobias (3)
  Michelle J. Brotzman (4)
  Stephen J. Chanock (3) (45)
  Rachael Z. Stolzenberg-Solomon (3)
  Alan A. Arslan (5) (6) (7)
  H. Bas Bueno-de-Mesquita (8) (9)
  Kathy Helzlsouer (10)
  Eric J. Jacobs (13)
  Andrea LaCroix (14)
  Gloria Petersen (15)
  Wei Zheng (16)
  Demetrius Albanes (3)
  Naomi E. Allen (17)
  Laufey Amundadottir (3) (45)
  Ying Bao (18)
  Heiner Boeing (19)
  Marie-Christine Boutron-Ruault (20)
  Julie E. Buring (21) (22)
  J. Michael Gaziano (23) (24)
  Edward L. Giovannucci (25) (26) (27)
  Eric J. Duell (28)
  G?ran Hallmans (29)
  Barbara V. Howard (30)
  David J. Hunter (25) (26)
  Amy Hutchinson (31) (45)
  Kevin B. Jacobs (3)
  Charles Kooperberg (14)
  Peter Kraft (25)
  Julie B. Mendelsohn (3)
  Dominique S. Michaud (32) (33)
  Domenico Palli (34)
  Lawrence S. Phillips (35) (36)
  Kim Overvad (37)
  Alpa V. Patel (13)
  Leah Sansbury (1) (38)
  Xiao-Ou Shu (16)
  Michael S. Simon (39)
  Nadia Slimani (40)
  Dimitrios Trichopoulos (25) (41)
  Kala Visvanathan (11) (12)
  Jarmo Virtamo (42)
  Brian M. Wolpin (18) (43)
  Anne Zeleniuch-Jacquotte (6) (7)
  Charles S. Fuchs (18) (43)
  Robert N. Hoover (3)
  Myron Gross (44)
  
  1. Division of Cancer Control and Population Science (DCCPS), National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
  2. Information Management Services, Silver Spring, MD, USA
  3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
  4. Westat, Inc, Rockville, MD, USA
  45. Laboratory of Translation Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
  5. Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
  6. Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
  7. New York University Cancer Institute, New York, NY, USA
  8. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
  9. Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
  10. Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA
  13. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA
  14. Fred Hutchinson Cancer Research Center, Seattle, WA, USA
  15. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
  16. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
  17. Cancer Epidemiology Unit, University of Oxford, Nuffield Department of Clinical Medicine, Oxford, UK
  18. Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  19. German Institute of Human Nutrition Potsdam-Rehbrüecke, Nuthetal, Germany
  20. Inserm, (Institut National de la Santé et de la Recherche Médicale) and Institut Gustave Roussy, Villejuif, France
  21. Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  22. Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA, USA
  23. Physicians-Health Study, Divisions of Aging, Cardiovascular Medicine, and Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  24. Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA
  25. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
  26. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
  27. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
  28. Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
  29. Department of Public Health and Clinical Medicine, Nutritional Research, Ume? University, Ume?, Sweden
  30. MedStar Health Research Institute, Georgetown University, Hyattsville, MD, USA
  31. Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA
  32. Division of Biology and Medicine, Brown University, Providence, RI, USA
  33. Division of Epidemiology, Public Health and Primary Care, Imperial College, London, UK
  34. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute–ISPO, Florence, Italy
  35. Division of Endocrinology, Emory University, Atlanta, GA, USA
  36. Atlanta VA Medical Center, Decatur, GA, USA
  37. Department of Epidemiology, School of Public Health, Aarhus University, Aalborg, Denmark
  38. Department of Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA
  39. Karmanos Cancer Institute, Department of Oncology, Wayne State University, Detroit, MI, USA
  40. International Agency for Research on Cancer, Lyon, France
  41. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece
  11. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
  12. Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
  42. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
  43. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
  44. Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA
  
• ISSN：1573-7225

文摘

Purpose Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case–control study design. Subjects who were diagnosed with diabetes near the time (<2?years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR?=?1.40, 95?% CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-?years (OR?=?1.79, 95?% CI: 1.25, 2.55); there was no association for those with 9+?years of diabetes (OR?=?1.02, 95?% CI: 0.68, 1.52). Conclusions These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.