Cerebral and Peripheral Metabolism to Predict Successful Reperfusion After Cardiac Arrest in Rats: A Microdialysis Study

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• 作者：A. Hosmann ; A. Schober ; A. Gruber ; F. Sterz ; C. Testori ; A. Warenits…
• 关键词：Neuromonitoring ; Microdialysis ; Cardiac arrest ; Resuscitation ; Reperfusion ; Cerebral metabolism ; Ischemia ; Animal model
• 刊名：Neurocritical Care
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：24
• 期：2
• 页码：283-293
• 全文大小：818 KB
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• 作者单位：A. Hosmann (1)
  A. Schober (2)
  A. Gruber (1)
  F. Sterz (2)
  C. Testori (2)
  A. Warenits (2)
  W. Weihs (2)
  S. Högler (3)
  T. Scherer (4)
  A. Janata (2)
  A. Laggner (2)
  Markus Zeitlinger (5)
  
  1. Department of Neurosurgery, Medical University of Vienna, Vienna, Austria
  2. Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria
  3. University of Veterinary Medicine, Vienna, Austria
  4. Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
  5. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
  
• 刊物主题：Internal Medicine; Neurology;
• 出版者：Springer US
• ISSN：1556-0961

文摘

Background In clinical practice, monitoring of the efficacy of resuscitation can be challenging. The prediction of cerebral and overall outcome in particular is an unmet medical need. Microdialysis is a minimally invasive technique for the continuous determination of metabolic parameters in vivo. Using this technique, we set out to establish a model allowing for concomitant determination of cerebral and peripheral metabolism in a cardiac arrest setting in rodents.