CD200 in growing rat lungs: developmental expression and control by dexamethasone

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• 作者：Mang-Hung Tsai (1)
  Chin-Chen Chu (2) (3)
  Tsui-Shan Wei (4)
  Mei-Miao Chiu (5)
  Chiu-Yun Chang (6)
  I-Hua Wei (1)
  Hsiung-Fei Chien (7)
  Hui-Min Chen (6) (8)
  Ching-Hsiang Wu (6)
  Ya-Fen Jiang-Shieh (4)
  
  1. Department of Anatomy ; China Medical University ; Taichung ; 404 ; Taiwan
  2. Department of Anesthesiology ; Chi Mei Medical Center ; Tainan ; 710 ; Taiwan
  3. Department of Recreation and Health-Care Management ; Chia Nan University of Pharmacy and Science ; Tainan ; 717 ; Taiwan
  4. Department of Anatomy ; College of Medicine ; National Cheng Kung University ; No. 1 University Road ; Tainan ; 701 ; Taiwan
  5. Institute of Anatomy and Cell Biology ; School of Medicine ; National Yang-Ming University ; Taipei ; 112 ; Taiwan
  6. Department of Anatomy ; College of Medicine ; Taipei Medical University ; Taipei ; 110 ; Taiwan
  7. Department of Surgery ; College of Medicine ; National Taiwan University ; No. 250 Wu-Hsing Street ; Taipei ; 110 ; Taiwan
  8. Electron Microscopy Center ; College of Medicine ; Taipei Medical University ; Taipei ; 110 ; Taiwan
  
• 关键词：CD200 ; Alveolar endothelium ; Development ; Pulmonary ; Dexamethasone ; Rat (Wistar)
• 刊名：Cell and Tissue Research
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：359
• 期：3
• 页码：729-742
• 全文大小：3,315 KB
• 参考文献：1. Attar, MA, Bailie, MB, Christensen, PJ, Brock, TG, Wilcoxen, SE, Paine, R (1999) Induction of ICAM-1expression on alveolar epithelial cells during lung development in rats and humans. Exp Lung Res 25: pp. 245-259 80/019021499270295" target="_blank" title="It opens in new window">CrossRef
  2. Barclay, AN (1981) Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy-1 and MRC OX 2 antigens. Immunology 44: pp. 727-736
  3. Barclay, AN (2003) Membrane proteins with immunoglobulin-like domains鈥攁 master superfamily of interaction molecules. Semin Immunol 15: pp. 215-223 CrossRef
  4. Berg, T, Cassel, TN, Schwarze, PE, Nord, M (2002) Glucocorticoids regulate the CCSP and CYP2B1 promoters via C/EBPbeta and delta in lung cells. Biochem Biophys Res Commun 293: pp. 907-912 CrossRef
  5. Bhatt, AJ, Amin, SB, Chess, PR, Watkins, RH, Maniscalco, WM (2000) Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung. Pediatr Res 47: pp. 606-613 CrossRef
  6. Bolt, RJ, Weissenbruch, MM, Lafeber, HN, Delemarre-van de Waal, HA (2001) Glucocorticoids and lung development in the fetus and preterm infant. Pediatr Pulmonol 32: pp. 76-91 CrossRef
  7. Broderick, C, Hoek, RM, Forrester, JV, Liversidge, J, Sedgwick, JD, Dick, AD (2002) Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 161: pp. 1669-1677 CrossRef
  8. Bukovsk媒, A, Presl, J, Zidovsk媒, J, Mancal, P (1983) The localization of Thy-1.1, MRC OX 2 and Ia antigens in the rat ovary and fallopian tube. Immunology 48: pp. 587-596
  9. Burri, PH (1984) Fetal and postnatal development of the lung. Annu Rev Physiol 46: pp. 617-628 84.003153" target="_blank" title="It opens in new window">CrossRef
  10. Burri, PH (2006) Structural aspects of postnatal lung development鈥攁lveolar formation and growth. Biol Neonate 89: pp. 313-322 868" target="_blank" title="It opens in new window">CrossRef
  11. Burri, PH, Tarek, MR (1990) A novel mechanism of capillary growth in the rat pulmonary microcirculation. Anat Rec 228: pp. 35-45 80107" target="_blank" title="It opens in new window">CrossRef
  12. Chang, CY, Lee, YH, Jiang-Shieh, YF, Chien, HF, Pai, MH, Chen, HM, Fong, TH, Wu, CH (2011) Novel distribution of cluster of differentiation 200 adhesion molecule in glial cells of the peripheral nervous system of rats and its modulation after nerve injury. Neuroscience 183: pp. 32-46 CrossRef
  13. Chen, Z, Marsden, PA, Gorczynski, RM (2006) Cloning and characterization of the human CD200 promoter region. Mol Immunol 43: pp. 579-587 CrossRef
  14. Chen, Z, Marsden, PA, Gorczynski, RM (2009) Role of a distal enhancer in the transcriptional responsiveness of the human CD200 gene to interferon-gamma and tumor necrosis factor-alpha. Mol Immunol 46: pp. 1951-1963 CrossRef
  15. Chiu, JF, Massari, RJ, Schwartz, CE, Meisler, NT, Thanassi, JW (1981) Hormonal modulation of alpha-fetoprotein gene expression in newborn rat livers. Nucleic Acids Res 9: pp. 6917-6933 CrossRef
  16. Danese, S, Dejana, E, Fiocchi, C (2007) Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 178: pp. 6017-6022 8.10.6017" target="_blank" title="It opens in new window">CrossRef
  17. Dick, AD, Broderick, C, Forrester, JV, Wright, GJ (2001) Distribution of OX2 antigen and OX2 receptor within retina. Invest Ophthalmol Vis Sci 42: pp. 170-176
  18. Dickie, R, Tasat, DR, Alanis, EF, Delfosse, V, Tsuda, A (2009) Age-dependent changes in porcine alveolar macrophage function during the postnatal period of alveolarization. Dev Comp Immunol 33: pp. 145-151 8.07.016" target="_blank" title="It opens in new window">CrossRef
  19. Gorczynski, RM, Cattral, MS, Chen, Z, Hu, J, Lei, J, Min, WP, Yu, G, Ni, J (1999) An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival. J Immunol 163: pp. 1654-1660
  20. Gorczynski, RM, Hadidi, S, Yu, G, Clark, DA (2002) The same immunoregulatory molecules contribute to successful pregnancy and transplantation. Am J Reprod Immunol 48: pp. 18-26 897.2002.01094.x" target="_blank" title="It opens in new window">CrossRef
  21. Gordon, PV, Moats-Staats, BM, Stiles, AD, Price, WA (2002) Dexamethasone changes the composition of insulin-like growth factor binding proteins in the newborn mouse ileum. J Pediatr Gastroenterol Nutr 35: pp. 532-538 CrossRef
  22. Grier, DG, Halliday, HL (2004) Effects of glucocorticoids on fetal and neonatal lung development. Treat Respir Med 3: pp. 295-306 829-200403050-00004" target="_blank" title="It opens in new window">CrossRef
  23. Hoek, RM, Ruuls, SR, Murphy, CA, Wright, GJ, Goddard, R, Zurawski, SM, Blom, B, Homola, ME, Streit, WJ, Brown, MH, Barclay, AN, Sedgwick, JD (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290: pp. 1768-1771 8" target="_blank" title="It opens in new window">CrossRef
  24. Jacobs, RF, Wilson, CB, Palmer, S, Springmeyer, SC, Henderson, WR, Glover, DM, Kessler, DL, Murphy, JH, Hughes, JP, Belle, G, Chi, EY, Hodson, WA (1985) Factors related to the appearance of alveolar macrophages in the developing lung. Am Rev Respir Dis 131: pp. 548-553
  25. Jiang-Shieh, YF, Chien, HF, Chang, CY, Wei, TS, Chiu, MM, Chen, HM, Wu, CH (2010) Distribution and expression of CD200 in the rat respiratory system under normal and endotoxin-induced pathological conditions. J Anat 216: pp. 407-416 80.2009.01190.x" target="_blank" title="It opens in new window">CrossRef
  26. Ko, YC, Chien, HF, Jiang-Shieh, YF, Chang, CY, Pai, MH, Huang, JP, Chen, HM, Wu, CH (2009) Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions. J Anat 214: pp. 183-195 80.2008.00986.x" target="_blank" title="It opens in new window">CrossRef
  27. Kolla, V, Gonzales, LW, Bailey, NA, Wang, P, Angampalli, S, Godinez, MH, Madesh, M, Ballard, PL (2009) Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein. Am J Physiol Lung Cell Mol Physiol 296: pp. L1019-L1030 8" target="_blank" title="It opens in new window">CrossRef
  28. Koning, N, B枚, L, Hoek, RM, Huitinga, I (2007) Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann Neurol 62: pp. 504-514 CrossRef
  29. Lin, Y, Lechner, AJ (1991) Development of alveolar septa and cellular maturation within the perinatal lung. Am J Respir Cell Mol Biol 4: pp. 59-64 CrossRef
  30. Maeda, S, Suzuki, S, Suzuki, T, Endo, M, Moriya, T, Chida, M, Kondo, T, Sasano, H (2002) Analysis of intrapulmonary vessels and epithelial-endothelial interactions in the human developing lung. Lab Invest 82: pp. 293-301 8/labinvest.3780423" target="_blank" title="It opens in new window">CrossRef
  31. Mariani, TJ, Reed, JJ, Shapiro, SD (2002) Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix. Am J Respir Cell Mol Biol 26: pp. 541-548 80c" target="_blank" title="It opens in new window">CrossRef
  32. Marszalek, A, Daa, T, Kashima, K, Nakayama, I, Yokoyama, S (2000) Ultrastructural and morphometric studies related to expression of the cell adhesion molecule PECAM-1/CD31 in developing rat lung. J Histochem Cytochem 48: pp. 1283-1289 800911" target="_blank" title="It opens in new window">CrossRef
  33. Marszalek, A, Daa, T, Kashima, K, Nakayama, I, Yokoyama, S (2001) Quantitative immunohistochemical analysis of the expression of CD31 during lung development in the rat. Cells Tissues Organs 169: pp. 49-54 860" target="_blank" title="It opens in new window">CrossRef
  34. Massaro, D, Massaro, GD (1986) Dexamethasone accelerates postnatal alveolar wall thinning and alters wall composition. Am J Physiol 251: pp. R218-R224
  35. McMaster, WR, Williams, AF (1979) Identification of Ia glycoproteins in rat thymus and purification from rat spleen. Eur J Immunol 9: pp. 426-433 830090603" target="_blank" title="It opens in new window">CrossRef
  36. McMenamy, KR, Anderson, MJ, Zachman, RD (1994) Effect of dexamethasone and oxygen exposure on neonatal rat lung retinoic acid receptor proteins. Pediatr Pulmonol 18: pp. 232-238 80407" target="_blank" title="It opens in new window">CrossRef
  37. Moschopulos, M, Burri, PH (1993) Morphometric analysis of fetal rat lung development. Anat Rec 237: pp. 38-48 CrossRef
  38. Preston, S, Wright, GJ, Starr, K, Barclay, AN, Brown, MH (1997) The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages. Eur J Immunol 27: pp. 1911-1918 830270814" target="_blank" title="It opens in new window">CrossRef
  39. Roth-Kleiner, M, Berger, TM, Tarek, MR, Burri, PH, Schittny, JC (2005) Neonatal dexamethasone induces premature microvascular maturation of the alveolar capillary network. Dev Dyn 233: pp. 1261-1271 CrossRef
  40. Rygiel, TP, Rijkers, ES, Ruiter, T, Stolte, EH, Valk, M, Rimmelzwaan, GF, Boon, L, Loon, AM, Coenjaerts, FE, Hoek, RM, Tesselaar, K, Meyaard, L (2009) Lack of CD200 enhances pathological T cell responses during influenza infection. J Immunol 183: pp. 1990-1996 CrossRef
  41. Snelgrove, RJ, Goulding, J, Didierlaurent, AM, Lyonga, D, Vekaria, S, Edwards, L, Gwyer, E, Sedgwick, JD, Barclay, AN, Hussell, T (2008) A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol 9: pp. 1074-1083 8/ni.1637" target="_blank" title="It opens in new window">CrossRef
  42. Southwood, M, Jeffery, TK, Yang, X, Upton, PD, Hall, SM, Atkinson, C, Haworth, SG, Stewart, S, Reynolds, PN, Long, L, Trembath, RC, Morrell, NW (2008) Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J Pathol 214: pp. 85-95 CrossRef
  43. Tsao, PN, Li, H, Wei, SC, Ko, ML, Chou, HC, Hsieh, WS, Hsieh, FJ (2004) Expression of angiogenic factors and their receptors in postnatal mouse developing lung. J Formos Med Assoc 103: pp. 137-143
  44. Tschanz, SA, Damke, BM, Burri, PH (1995) Influence of postnatally administered glucocorticoids on rat lung growth. Biol Neonate 68: pp. 229-245 CrossRef
  45. Walker, DG, Dalsing-Hernandez, JE, Campbell, NA, Lue, LF (2009) Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation. Exp Neurol 215: pp. 5-19 8.09.003" target="_blank" title="It opens in new window">CrossRef
  46. Yang, H, Mammen, J, Wei, W, Menconi, M, Evenson, A, Fareed, M, Petkova, V, Hasselgren, PO (2005) Expression and activity of C/EBPbeta and delta are upregulated by dexamethasone in skeletal muscle. J Cell Physiol 204: pp. 219-226 8" target="_blank" title="It opens in new window">CrossRef
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

CD200 belongs to cell adhesion molecules of the immunoglobulin superfamily. It lacks intracellular signaling motifs and exerts immunosuppressive effect in various tissues. We have reported previously that CD200 is predominantly associated with the capillary network in the alveolar septum of adult rats. The alveolar endothelial cells express CD200, which is confined to their luminal cell membrane facing the blood-air barrier. Our present results show that lung CD200 protein increases gradually with advancing age, being maximally expressed in the early postnatal (P) period. CD200 protein expression, however, declines at P5 but increases again after P7, reaching the adult level at P21. In developing lungs in fetal and neonatal stages, double-immunofluorescence staining has confirmed intense CD200 immunoreactivity delineating the vascular profiles in the double layers of the alveolar capillaries; this staining becomes diffuse and patchy with time. Unlike in adult lungs, immunoelectron microscopy has revealed that CD200 expression in fetal and early postnatal lungs is localized over the entire luminal cell membrane and in the cytoplasm of the endothelia. CD200 expression is progressively redistributed to a specific luminal domain of alveolar endothelia during pulmonary microvascular maturation. In neonatal rats treated with dexamethasone, the amount of lung CD200 significantly increases and is also elevated with time. Upregulation of endothelial CD200 has further been confirmed in isolated pulmonary microvascular endothelial cells treated with dexamethasone. Thus, lung CD200 is developmentally regulated, possibly under hormonal influence.