Evaluation of the Xpert® MTB/RIF assay and microscopy for the diagnosis of Mycobacterium tuberculosis in Namibia

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• 作者：Rooyen T. Mavenyengwa ; Emma Shaduka ; Innocent Maposa
• 关键词：Tuberculosis ; Xpert® MTB/RIF assay ; Microscopy ; Diagnostic tests ; Rifampicin ; Namibia
• 刊名：Infectious Diseases of Poverty
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：6
• 期：1
• 全文大小：362KB
• 刊物主题：Infectious Diseases; Tropical Medicine; Public Health;
• 出版者：BioMed Central
• ISSN：2049-9957
• 卷排序：6

文摘

BackgroundTuberculosis (TB) kills approximately two million people and infects around nine million worldwide annually. Its proper management, especially in resource-limited settings, has been hindered by the lack of rapid and easy-to-use diagnostic tests. Sputum smear microscopy remains the cheapest, readily available diagnostic method but it only identifies less than half of the patients with a HIV/TB co-infection because the bacilli would have disseminated from the lungs to other areas of the body. The fully automated Xpert® MTB/RIF assay is a promising innovation for diagnosing TB and detecting resistance to rifampicin. This study aimed to evaluate the use of Xpert® MTB/RIF assay and microscopy in the diagnosis of Mycobacterium tuberculosis in Namibia, by determining the disease’s epidemiology and calculating the proportion of cases infected just with TB and those with a resistance to rifampicin among the total suspected cases of TB in the country.