The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development

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• 作者：Burcu Erdogan ; Garrett M. Cammarata ; Eric J. Lee ; Benjamin C. Pratt…
• 关键词：Microtubule ; +TIPs ; TACC3 ; XMAP215 ; Xenopus laevis ; Neuronal development ; Growth cone ; Axon guidance
• 刊名：Neural Development
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：2352KB
• 刊物主题：Neurosciences; Developmental Biology; Neurobiology;
• 出版者：BioMed Central
• ISSN：1749-8104
• 卷排序：12

文摘

BackgroundFormation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and their plus-end tracking proteins (+TIPs) are thought to play integrative roles during this navigation. TACC3 is a + TIP that we have previously implicated in regulating MT dynamics within axons. However, the role of TACC3 in axon guidance has not been previously explored.