Paternal intake of folate and vitamins B6 and B12 before conception and risk of childhood acute lymphoblastic leukemia
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- 作者：Helen D. Bailey (1) (2)
Margaret Miller (3)
Kathryn R. Greenop (2)
Carol Bower (2)
John Attia (4) (5)
Glenn M. Marshall (6)
Bruce K. Armstrong (7) (8)
Elizabeth Milne (2) - 关键词：Epidemiology ; Child ; Leukemia ; Folate ; Vitamin B6 ; Vitamin B12
- 刊名：Cancer Causes and Control
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：25
- 期：12
- 页码：1615-1625
- 全文大小：203 KB
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Kathryn R. Greenop (2)
Carol Bower (2)
John Attia (4) (5)
Glenn M. Marshall (6)
Bruce K. Armstrong (7) (8)
Elizabeth Milne (2)
1. Section of Environment and Radiation, International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France
2. Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia
3. Child Health Promotion Research Centre, School of Exercise and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
4. Faculty of Health, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
5. Hunter Medical Research Institute, John Hunter Hospital, New Lambton, NSW, Australia
6. Kids Cancer Centre, Sydney Children’s Hospital, Children’s Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, NSW, Australia
7. Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia
8. Sax Institute, Ultimo, NSW, Australia - ISSN：1573-7225
文摘
Purpose We investigated whether paternal dietary intake of folate before conception is associated with the risk of childhood acute lymphoblastic leukemia (ALL) in a nationwide case–control study. Methods Data on dietary folate intake during the 6?months before the child’s conception were collected from 285 case fathers and 595 control fathers using a dietary questionnaire. Nutrient intake was quantified using a customized computer software package based on Australian food composition databases. Data on folate intake were analyzed using unconditional logistic regression, adjusting for study-matching variables, total energy, and potentially confounding variables. In a subset of 229 cases and 420 controls, data on vitamin B6 and vitamin B12 intake were also analyzed. Results No consistent associations were seen with paternal dietary intake of folate or vitamin B6. Higher levels of paternal dietary vitamin B12 were appeared to be associated with an increased risk of childhood ALL, with those in the highest tertile of consumption having an OR of 1.51 (0.97, 2.36). The use of supplements containing folate and vitamins B6 or B12 was rare. Conclusions We did not find any biologically plausible evidence that paternal nutrition in the period leading up to conception was associated with childhood ALL. Our finding for vitamin B12 may be a chance finding, given the number of analyses performed, or be attributable to participation bias because parents with a tertiary education had the lowest level of B12 intake and tertiary education was more common among control than case parents.