Hybrid de novo genome assembly of the Chinese herbal plant danshen (Salvia miltiorrhiza Bunge)
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- 作者：Guanghui Zhang ; Yang Tian ; Jing Zhang ; Liping Shu ; Shengchao Yang ; Wen Wang…
- 关键词：Salvia miltiorrhiza Bunge ; Illumina sequencing ; PacBio sequencing ; High heterozygous genome assembly
- 刊名：GigaScience
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：4
- 期：1
- 全文大小：411 KB
- 刊物主题：Bioinformatics; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Proteomics; Data Mining and Knowledge Discovery;
- 出版者：BioMed Central
- ISSN：2047-217X
文摘
Background Danshen (Salvia miltiorrhiza Bunge), also known as Chinese red sage, is a member of Lamiaceae family. It is valued in traditional Chinese medicine, primarily for the treatment of cardiovascular and cerebrovascular diseases. Because of its pharmacological potential, ongoing research aims to identify novel bioactive compounds in danshen, and their biosynthetic pathways. To date, only expressed sequence tag (EST) and RNA-seq data for this herbal plant are available to the public. We therefore propose that the construction of a reference genome for danshen will help elucidate the biosynthetic pathways of important secondary metabolites, thereby advancing the investigation of novel drugs from this plant.