The prognosis and clinicopathology of CXCR4 in gastric cancer patients: a meta-analysis

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• 作者：Mingzhi Han (1)
  Shunzeng Lv (1) (2)
  Ya Zhang (3)
  Ruiyang Yi (4)
  Bin Huang (1)
  Hanhui Fu (1)
  Ruixiang Bian (5)
  Xingang Li (1)
  
• 关键词：CXCR4 ; Gastric cancer ; Prognosis ; Clinicopathology ; Meta ; analysis
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：35
• 期：5
• 页码：4589-4597
• 全文大小：
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• 作者单位：Mingzhi Han (1)
  Shunzeng Lv (1) (2)
  Ya Zhang (3)
  Ruiyang Yi (4)
  Bin Huang (1)
  Hanhui Fu (1)
  Ruixiang Bian (5)
  Xingang Li (1)
  
  1. Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, NO.44 West Wenhua Road, Jinan, Shandong, People’s Republic of China
  2. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People′s Republic of China
  3. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People′s Republic of China
  4. Biological Sciences Division, University of Chicago, Chicago, IL, USA
  5. Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People′s Republic of China
  
• ISSN：1423-0380

文摘

The chemokine receptor 4 (CXCR4) has been widely investigated in diagnosis and prognosis of gastric cancer (GC). However, the impact of CXCR4 on GC patients remains controversial; Here, we conducted a meta-analysis to obtain the precise role of CXCR4 in GC prognosis and clinicopathology. Thirteen published studies with a total of 1,936 patients were included. Original data included the hazard ratio (HR) of overall survival (OS) and odds ratio (OR) in GC patients. We combined HR/OR with 95?% confidence interval (CI) to estimate the hazard. In this study, OS was significantly related to CXCR4 expression, with the HR 2.63 (95?% CI 1.69-.09; p-lt;-.0001), and a significant correlation was also revealed between CXCR4 expression and stage (I-?II, +) (OR 0.52, 95?% CI 0.32-.83; p--.007), depth of invasion (T1/T2, +) (OR 0.44, 95?% CI 0.27-.73; p--.001), lymph node metastasis (LN, +) (OR 2.30, 95?% CI 1.57-.36; p-lt;-.0001), as well as vascular invasion (vas.inv, +) (OR 0.72, 95?% CI 0.53-.98; p--.04). Heterogeneity was observed among the included studies with OS (I 2--1?%), stage (I 2--8?%), depth of invasion (I 2--4?%), lymph node metastasis (I 2--4?%), and histology differentiation (I 2--9?%). No publication bias was observed. In conclusion, this meta-analysis showed CXCR4 expression indicates poor prognosis in GC patients with advanced stage or deep invasion in GC tissues, which also implied lymph node metastasis and vascular invasion. Thus, CXCR4 could help predict patient prognosis and guide clinical diagnosis and treatment.