Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures
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- 作者：Ming-Tao Yang ; Yi-Chin Lin ; Whae-Hong Ho ; Chao-Lin Liu…
- 关键词：Epilepsy ; ERK ; Everolimus ; Kainic acid ; mTOR ; Neuroinflammation ; Rapamycin
- 刊名：Journal of Neuroinflammation
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：1048KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
- 卷排序：14
文摘
BackgroundMicroglia is responsible for neuroinflammation, which may aggravate brain injury in diseases like epilepsy. Mammalian target of rapamycin (mTOR) kinase is related to microglial activation with subsequent neuroinflammation. In the present study, rapamycin and everolimus, both as mTOR inhibitors, were investigated in models of kainic acid (KA)-induced seizure and lipopolysaccharide (LPS)-induced neuroinflammation.