Evaluation of immune responses of gastric cancer patients treated by laparoscopic and open gastrectomy

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• 作者：Ming Cui ; Chaofan Gong ; Beihai Jiang ; Zhendan Yao ; Lei Chen ; Jiabo Di…
• 关键词：Gastric cancer ; Laparoscopy ; Gastrectomy ; Immune response ; Cytokine
• 刊名：Medical Oncology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：32
• 期：11
• 全文大小：1,707 KB
• 参考文献：1.Goh P, Tekant Y, Isaac J, Kum CK, Ngoi SS. The technique of laparoscopic Billroth II gastrectomy. Surg Laparosc Endosc. 1992;2:258-0.PubMed
  2.Cui M, Li Z, Xing J, Yao Z, Liu M, Chen L, Zhang C, Yang H, Zhang N, Tan F, Jiang B, Di J, Wang Z, Ji J, Su X. A prospective randomized clinical trial comparing D2 dissection in laparoscopic and open gastrectomy for gastric cancer. Med Oncol. 2015;32:680.PubMed
  3.Kim W, Kim HH, Han SU, Kim MC, Hyung WJ, Ryu SW, Cho GS, Kim CY, Yang HK, Park DJ, Song KY, Lee SI, Ryu SY, Lee JH, Lee HJ, Korean Laparo-endoscopic Gastrointestinal Surgery Study (KLASS) Group. Decreased morbidity of laparoscopic distal gastrectomy compared with open distal gastrectomy for stage I gastric cancer: short-term outcomes from a multicenter randomized controlled trial (KLASS-01). Ann Surg. 2015. doi:10.-097/?SLA.-000000000001346-/span> .
  4.Quan Y, Huang A, Ye M, Xu M, Zhuang B, Zhang P, Yu B, Min Z. Comparison of laparoscopic versus open gastrectomy for advanced gastric cancer: an updated meta-analysis. Gastric Cancer. 2015. doi:10.-007/?s10120-015-0516-x .PubMed
  5.Kimura A, Ogata K, Kogure N, Yanoma T, Suzuki M, Toyomasu Y, Ohno T, Mochiki E, Kuwano H. Outcome of laparoscopic gastrectomy with D1 plus lymph node dissection in gastric cancer patients postoperatively diagnosed with locally advanced disease or lymph node metastasis. Surg Endosc. 2015. doi:10.-007/?s00464-015-4462-9 .
  6.Chen XZ, Wen L, Rui YY, Liu CX, Zhao QC, Zhou ZG, Hu JK. Long-term survival outcomes of laparoscopic versus open gastrectomy for gastric cancer: a systematic review and meta-analysis. Medicine (Baltimore). 2015;94:e454.CrossRef
  7.Okholm C, Goetze JP, Svendsen LB, Achiam MP. Inflammatory response in laparoscopic vs. open surgery for gastric cancer. Scand J Gastroenterol. 2014;49:1027-4.CrossRef PubMed
  8.Karanika S, Karantanos T, Theodoropoulos GE. Immune response after laparoscopic colectomy for cancer: a review. Gastroenterol Rep (Oxf). 2013;1:85-4.CrossRef
  9.Wu MH, Wang MY, Yang CY, Lee PH, Lin MT. Inflammatory response attenuation in patients undergoing gasless laparoscopic gastrectomy. Hepatogastroenterology. 2013;60:439-2.PubMed
  10.Cui M, Xing JD, Yang W, Ma YY, Yao ZD, Zhang N, Su XQ. D2 dissection in laparoscopic and open gastrectomy for gastric cancer. World J Gastroenterol. 2012;18:833-.PubMed Central CrossRef PubMed
  11.Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-0.CrossRef PubMed
  12.Adachi Y, Shiraishi N, Shiromizu A, Bandoh T, Aramaki M, Kitano S. Laparoscopy-assisted Billroth I gastrectomy compared with conventional open gastrectomy. Arch Surg. 2000;135:806-0.CrossRef PubMed
  13.Shu ZB, Cao HP, Li YC, Sun LB. Influences of laparoscopic-assisted gastrectomy and open gastrectomy on serum interleukin-6 levels in patients with gastric cancer among Asian populations: a systematic review. BMC Gastroenterol. 2015;15:52.PubMed Central CrossRef PubMed
  14.Ishikawa M, Nishioka M, Hanaki N, Miyauchi T, Kashiwagi Y, Ioki H, Kagawa A, Nakamura Y. Perioperative immune responses in cancer patients undergoing digestive surgeries. World J Surg Oncol. 2009;7:7.PubMed Central CrossRef PubMed
  15.Jung IK, Kim MC, Kim KH, Kwak JY, Jung GJ, Kim HH. Cellular and peritoneal immune response after radical laparoscopy-assisted and open gastrectomy for gastric cancer. J Surg Oncol. 2008;98:54-.CrossRef PubMed
  16.Fujii K, Sonoda K, Izumi K, Shiraishi N, Adachi Y, Kitano S. T lymphocyte subsets and Th1/Th2 balance after laparoscopy-assisted distal gastrectomy. Surg Endosc. 2003;17:1440-.CrossRef PubMed
  17.Choi YB. Laparoscopic gatrojejunostomy for palliation of gastric outlet obstruction in unresectable gastric cancer. Surg Endosc. 2002;16:1620-.CrossRef PubMed
  
• 作者单位：Ming Cui (1)
  Chaofan Gong (1)
  Beihai Jiang (1)
  Zhendan Yao (1)
  Lei Chen (1)
  Jiabo Di (1)
  Jiadi Xing (1)
  Hong Yang (1)
  Chenghai Zhang (1)
  Nan Zhang (1)
  Maoxing Liu (1)
  Fei Tan (1)
  Zaozao Wang (1)
  Xiangqian Su (1)
  
  1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China
  
• 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-131X

文摘

Laparoscopic surgery has been shown to offer more advantages than open surgery for the treatment of gastric cancer. However, the perioperative immune responses after laparoscopic surgery remain largely unexplored. Here, we analyzed the immunity of gastric cancer patients treated by laparoscopy-assisted gastrectomy (LAG) or open gastrectomy (OG) with D2 dissection. Seventy patients were randomized into LAG and OG groups. The operative details and postoperative outcomes of the two groups were compared. The immune factors were measured preoperatively as well as on the first, third, and seventh postoperative days (POD). Our results indicate that there was no significant difference between two groups in clinical characteristics. The profiles of white blood cells, neutrophils, lymphocytes, as well as the lymphocyte subpopulations, including T lymphocytes, B lymphocytes, CD4+ T cells, and CD8+ T cells were similar in the LAG and the OG groups. Only the natural killer cell counts were significantly higher in LAG-treated patients than in OG-treated ones on POD7. Moreover, no statistical differences were found between the two groups with respect to the levels of perioperative cytokines, including IFN-γ, IL-4, IL-6, and TNF-α. However, compared with the OG group, most of the immune factors in the LAG group had trends to return to preoperative levels on POD7. Our study demonstrates that the immune function of LAG-treated patients showed patterns similar to that of OG-treated patients, although larger prospective multicenter trials are needed to further evaluate the immunological status of LAG. Keywords Gastric cancer Laparoscopy Gastrectomy Immune response Cytokine