Identification of differential microRNA expression during tooth morphogenesis in the heterodont dentition of miniature pigs, SusScrofa
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- 作者：Ang Li ; Ye Li ; Tieli Song ; Fu Wang ; Dayong Liu ; Zhipeng Fan…
- 关键词：Odontogenesis ; Morphogenesis ; Microarray analysis ; In situ hybridization ; Miniature swine
- 刊名：BMC Developmental Biology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,770 KB
- 刊物主题：Developmental Biology; Animal Models; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-213X
文摘
Background It has been found that microRNAs (miRNAs) play important roles in the regulation of tooth development, and most likely increase the complexity of the genetic network, thus lead to greater complexity of teeth. But there has been no research about the key microRNAs associated with tooth morphogenesis based on miRNAs expression profiles. Compared to mice, the pig model has plentiful types of teeth, which is similar with the human dental pattern. Therefore, we used miniature pigs as large-animal models to investigate differentially expressed miRNAs expression during tooth morphogenesis in the early developmental stages of tooth germ.