Clinical Presentation, Diagnosis and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD) in Older Adults: A Review of the Evidence and its Implications for Clinical Care

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• 作者：David W. Goodman ; Sara Mitchell ; Lauren Rhodewalt ; Craig B. H. Surman
• 刊名：Drugs & Aging
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：33
• 期：1
• 页码：27-36
• 全文大小：457 KB
• 参考文献：1.Vincent GK, Velkoff VA. The next four decades: the older population in the United States: 2010 to 2050. Washington, DC: US Census Bureau; 2010.
  2.Akutagava-Martins GC, Salatino-Oliveira A, Kieling CC, Rohde LA, Hutz MH. Genetics of attention-deficit/hyperactivity disorder: current findings and future directions. Expert Rev Neurother. 2013;13(4):435–45.PubMed CrossRef
  3.Klein RG, Mannuzza S, Olazagasti MA, Roizen E, Hutchison JA, Lashua EC, et al. Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Arch Gen Psychiatry. 2012;69(12):1295–303.PubMed PubMedCentral CrossRef
  4.Goodman DW. The consequences of attention-deficit/hyperactivity disorder in adults. J Psychiatr Pract. 2007;13(5):318–27.PubMed CrossRef
  5.Bernardi S, Faraone SV, Cortese S, Kerridge BT, Pallanti S, Wang S, et al. The lifetime impact of attention deficit hyperactivity disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Psychol Med. 2012;42(4):875–87.PubMed PubMedCentral CrossRef
  6.Michielsen M, Semeijn E, Comijs HC, van de Ven P, Beekman AT, Deeg DJ, et al. Prevalence of attention-deficit hyperactivity disorder in older adults in The Netherlands. Br J Psychiatry. 2012;201(4):298–305.PubMed CrossRef
  7.de Zwaan M, Gruss B, Muller A, Graap H, Martin A, Glaesmer H, et al. The estimated prevalence and correlates of adult ADHD in a German community sample. Eur Arch Psychiatry Clin Neurosci. 2012;262(1):79–86.PubMed CrossRef
  8.Guldberg-Kjar T, Johansson B. Old people reporting childhood AD/HD symptoms: retrospectively self-rated AD/HD symptoms in a population-based Swedish sample aged 65–80. Nord J Psychiatry. 2009;63(5):375–82.PubMed CrossRef
  9.Kessler RC, Adler LA, Gruber MJ, Sarawate CA, Spencer T, Van Brunt DL. Adult ADHD Self-Report Scale (ASRS) symptom checklist. Int J Methods Psychiatr Res. 2007;16(2):52–65.PubMed PubMedCentral CrossRef
  10.Simon V, Czobor P, Balint S, Meszaros A, Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009;194(3):204–11.PubMed CrossRef
  11.American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Publishing; 2013.
  12.Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163(4):716–23.PubMed PubMedCentral CrossRef
  13.Surman CB, Hammerness PG, Pion K, Faraone SV. Do stimulants improve functioning in adults with ADHD? A review of the literature. Eur Neuropsychopharmacol. 2013;23(6):528–33.PubMed CrossRef
  14.da Silva MA, Louza M. Case of a 67-year-old woman diagnosed with ADHD successfully treated with methylphenidate. J Atten Disord. 2008;11(6):623.PubMed CrossRef
  15.Henry E, Jones SH. Experiences of older adult women diagnosed with attention deficit hyperactivity disorder. J Women Aging. 2011;23(3):246–62.PubMed CrossRef
  16.Manor I, Rozen S, Zemishlani Z, Weizman A, Zalsman G. When does it end? Attention-deficit/hyperactivity disorder in the middle aged and older populations. Clin Neuropharmacol. 2011;34(4):148–54.PubMed CrossRef
  17.Michielsen M, Comijs HC, Aartsen MJ, Semeijn EJ, Beekman AT, Deeg DJ, et al. The relationships between ADHD and social functioning and participation in older adults in a population-based study. J Atten Disord. 2015;19(5):368–79.PubMed CrossRef
  18.Michielsen M, Comijs HC, Semeijn EJ, Beekman AT, Deeg DJ, Kooij JJ. Attention deficit hyperactivity disorder and personality characteristics in older adults in the general Dutch population. Am J Geriatr Psychiatry. 2014;22(12):1623–32.PubMed CrossRef
  19.Semeijn EJ, Kooij JJ, Comijs HC, Michielsen M, Deeg DJ, Beekman AT. Attention-deficit/hyperactivity disorder, physical health, and lifestyle in older adults. J Am Geriatr Soc. 2013;61(6):882–7.PubMed CrossRef
  20.Brod M, Schmitt E, Goodwin M, Hodgkins P, Niebler G. ADHD burden of illness in older adults: a life course perspective. Qual Life Res. 2012;21(5):795–9.PubMed CrossRef
  21.Lensing MB, Zeiner P, Sandvik L, Opjordsmoen S. Quality of life in adults aged 50+ with ADHD. J Atten Disord. 2015;19(5):405–13.PubMed CrossRef
  22.Barkley RA, Murphy KR, Fischer M. ADHD in adults: what the science says. New York: Guilford Press; 2010.
  23.Anstey KJ, Christensen H, Butterworth P, Easteal S, Mackinnon A, Jacomb T, et al. Cohort profile: the PATH through life project. Int J Epidemiol. 2012;41(4):951–60.PubMed CrossRef
  24.Murphy K, Barkley R. Prevalence of DSM-IV symptoms of ADHD in adult licensed drivers: implications for clinical diagnosis. J Atten Disord. 1996;1(3):147–61.CrossRef
  25.Guldberg-Kjar T, Sehlin S, Johansson B. ADHD symptoms across the lifespan in a population-based Swedish sample aged 65 to 80. Int Psychogeriatr. 2013;25(4):667–75.PubMed CrossRef
  26.Kooij JJ, Buitelaar JK, van den Oord EJ, Furer JW, Rijnders CA, Hodiamont PP. Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychol Med. 2005;35(6):817–27.
  27.Michielsen M, Comijs HC, Semeijn EJ, Beekman AT, Deeg DJ, Sandra Kooij JJ. The comorbidity of anxiety and depressive symptoms in older adults with attention-deficit/hyperactivity disorder: a longitudinal study. J Affect Disord. 2013;148(2–3):220–7.PubMed CrossRef
  28.Surman C, Biederman J, Spencer TJ, Faraone SV, Monuteaux MC, Petty CR, et al. Representativeness of participants in a clinical trial for attention-deficit/hyperactivity disorder? Comparison with adults from a large observational study. J Clin Psychiatry. 2010;72(12):1612–6.CrossRef
  29.Goodman D. Adult ADHD and comorbid depressive disorders: diagnostic challenges and treatment options. CNS Spectr. 2009;14(7 Suppl 6):5–7 (discussion 13–4).PubMed
  30.Goodman DW, Lasser RA, Babcock T, Pucci ML, Solanto MV. Managing ADHD across the lifespan in the primary care setting. Postgrad Med. 2011;123(5):14–26.PubMed CrossRef
  31.Ivanchak N, Fletcher K, Jicha GA. Attention-deficit/hyperactivity disorder in older adults: prevalence and possible connections to mild cognitive impairment. Curr Psychiatry Rep. 2012;14(5):552–60.PubMed PubMedCentral CrossRef
  32.Langa KM, Levine DA. The diagnosis and management of mild cognitive impairment: a clinical review. JAMA. 2014;312(23):2551–61.PubMed PubMedCentral CrossRef
  33.Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011;134(Pt 9):2456–77.PubMed PubMedCentral CrossRef
  34.Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993;43(2):250–60.PubMed CrossRef
  35.Tuite PJ, Krawczewski K. Parkinsonism: a review-of-systems approach to diagnosis. Semin Neurol. 2007;27(2):113–22.PubMed CrossRef
  36.Geschwind MD, Shu H, Haman A, Sejvar JJ, Miller BL. Rapidly progressive dementia. Ann Neurol. 2008;64(1):97–108.PubMed PubMedCentral CrossRef
  37.Beh SC, Muthusamy B, Calabresi P, Hart J, Zee D, Patel V, et al. Hiding in plain sight: a closer look at posterior cortical atrophy. Pract Neurol. 2015;15(1):5–13.PubMed CrossRef
  38.McAllister TW, Arciniegas D. Evaluation and treatment of postconcussive symptoms. NeuroRehabilitation. 2002;17(4):265–83.PubMed
  39.Bucks RS, Olaithe M, Eastwood P. Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology. 2013;18(1):61–70.PubMed CrossRef
  40.Surman CB, Thomas RJ, Aleardi M, Pagano C, Biederman J. Adults with ADHD and sleep complaints: a pilot study identifying sleep-disordered breathing using polysomnography and sleep quality assessment. J Atten Disord. 2006;9(3):550–5.PubMed CrossRef
  41.Shpirer I, Elizur A, Shorer R, Peretz RB, Rabey JM, Khaigrekht M. Hypoxemia correlates with attentional dysfunction in patients with obstructive sleep apnea. Sleep Breath. 2012;16(3):821–7.PubMed CrossRef
  42.Fischer BL, Gunter-Hunt G, Steinhafel CH, Howell T. The identification and assessment of late-life ADHD in memory clinics. J Atten Disord. 2012;16(4):333–8.PubMed PubMedCentral CrossRef
  43.Golimstok A, Rojas JI, Romano M, Zurru MC, Doctorovich D, Cristiano E. Previous adult attention-deficit and hyperactivity disorder symptoms and risk of dementia with Lewy bodies: a case–control study. Eur J Neurol. 2011;18(1):78–84.PubMed CrossRef
  44.Ivanchak N, Abner EL, Carr SA, Freeman SJ, Seybert A, Ranseen J, et al. Attention-deficit/hyperactivity disorder in childhood is associated with cognitive test profiles in the geriatric population but not with mild cognitive impairment or Alzheimer’s disease. J Aging Res. 2011;2011:729801.PubMed PubMedCentral CrossRef
  45.Seidman LJ. Neuropsychological functioning in people with ADHD across the lifespan. Clin Psychol Rev. 2006;26(4):466–85.PubMed CrossRef
  46.Durell T, Adler L, Wilens T, Paczkowski M, Schuh K. Atomoxetine treatment for ADHD: younger adults compared with older adults. J Atten Disord. 2010;13(4):401–6.PubMed CrossRef
  47.Brod M, Pohlman B, Lasser R, Hodgkins P. Comparison of the burden of illness for adults with ADHD across seven countries: a qualitative study. Health Qual Life Outcomes. 2012;10:47.PubMed PubMedCentral CrossRef
  48.Lensing MB, Zeiner P, Sandvik L, Opjordsmoen S. Psychopharmacological treatment of ADHD in adults aged 50+: an empirical study. J Atten Disord. 2015;19(5):380–9.PubMed CrossRef
  49.Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ. Relative lack of cognitive effects of methylphenidate in elderly male volunteers. Psychopharmacology. 2003;168(4):455–64.PubMed CrossRef
  50.Herrmann N, Rothenburg LS, Black SE, Ryan M, Liu BA, Busto UE, et al. Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge. J Clin Psychopharmacol. 2008;28(3):296–301.PubMed CrossRef
  51.Hayashi M, Shimizu W, Albert CM. The spectrum of epidemiology underlying sudden cardiac death. Circ Res. 2015;116(12):1887–906.PubMed CrossRef
  52.Ermer J, Haffey MB, Richards C, Lasseter K, Adeyi B, Corcoran M, et al. Double-blind, placebo-controlled, two-period, crossover trial to examine the pharmacokinetics of lisdexamfetamine dimesylate in healthy older adults. Neuropsychiatr Dis Treat. 2013;9:219–29.PubMed PubMedCentral CrossRef
  53.Huang CC, Sandroni P, Sletten DM, Weigand SD, Low PA. Effect of age on adrenergic and vagal baroreflex sensitivity in normal subjects. Muscle Nerve. 2007;36(5):637–42.PubMed CrossRef
  54.Martinsson L, Yang X, Beck O, Wahlgren NG, Eksborg S. Pharmacokinetics of dexamphetamine in acute stroke. Clin Neuropharmacol. 2003;26(5):270–6.PubMed CrossRef
  55.Kraemer T, Maurer HH. Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives. Ther Drug Monit. 2002;24(2):277–89.PubMed CrossRef
  56.Adderall XR [package insert]. Wayne: Shire Pharmaceuticals Inc.; 2015.
  57.MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry. 1999;56(12):1073–86.CrossRef
  58.Knouse LE, Safren SA. Current status of cognitive behavioral therapy for adult attention-deficit hyperactivity disorder. Psychiatr Clin North Am. 2010;33(3):497–509.PubMed PubMedCentral CrossRef
  59.Young S, Khondoker M, Emilsson B, Sigurdsson JF, Philipp-Wiegmann F, Baldursson G, et al. Cognitive-behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis. Psychol Med. 2015;45(13):2793–804.PubMed PubMedCentral CrossRef
  
• 作者单位：David W. Goodman (1) (2) (3)
  Sara Mitchell (4)
  Lauren Rhodewalt (5)
  Craig B. H. Surman (5) (6)
  
  1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
  2. Adult Attention Deficit Disorder Center of Maryland, Lutherville, USA
  3. Suburban Psychiatric Associates, LLC Johns Hopkins at Green Spring Stations, 10751 Falls Rd, Suite 306, Baltimore, MD, 21093, USA
  4. Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, WAC 815, Boston, MA, 02114, USA
  5. Clinical and Research Program in ADHD and Related Disorders, Massachusetts General Hospital, 55 Fruit Street, Warren 631, Boston, MA, 02114, USA
  6. Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA
  
• 刊物主题：Geriatrics/Gerontology; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine;
• 出版者：Springer International Publishing
• ISSN：1179-1969

文摘

Although previously considered a disorder of childhood, studies in the last decade have demonstrated that attention-deficit hyperactivity disorder (ADHD) continues to impair function into adulthood and responds to pharmacotherapy. Due to age-specific changes in roles and challenges, it is possible that presentation and response to intervention may differ between older and younger adults. A literature search for papers that identified older adults with ADHD, including papers describing its epidemiology, manifestation, and treatment, was the basis for this paper. There is a paucity of data on ADHD in older adults; however, small observational studies have characterized the presence, impact, and treatment of ADHD in adults over the age of 50 years, and larger epidemiologic studies have demonstrated that ADHD symptoms exist in older adulthood. Optimal criteria for diagnosis of ADHD and methods of treating ADHD in older individuals have not been systematically explored. In light of the limited data, this review discusses considerations for differential diagnosis and safe pharmacotherapy of ADHD in older adults.