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The inverse association between serum 25-hydroxyvitamin D and mortality may be modified by vitamin A status and use of vitamin A supplements
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  • 作者:Einat Avital Schmutz ; Michael Bruce Zimmermann…
  • 关键词:Vitamin D ; Vitamin A ; Mortality ; NHANES III
  • 刊名:European Journal of Nutrition
  • 出版年:2016
  • 出版时间:February 2016
  • 年:2016
  • 卷:55
  • 期:1
  • 页码:393-402
  • 全文大小:551 KB
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  • 作者单位:Einat Avital Schmutz (1)
    Michael Bruce Zimmermann (1)
    Sabine Rohrmann (2)

    1. Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland
    2. Department of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland
  • 刊物类别:Chemistry and Materials Science
  • 刊物主题:Chemistry
    Nutrition
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1436-6215
文摘
Background Low serum 25-hydroxyvitamin D [25(OH)D] levels have been associated with higher risk of many diseases that affect mortality, including cardiovascular disease (CVD) and cancer. The inverse association between serum 25(OH)D and mortality may be modified by excess circulating vitamin A, due to interactions of vitamin A at the level of the vitamin D nuclear receptor. In this prospective cohort study, we investigated whether the association of 25(OH)D with all-cause, cancer, and CVD mortality was modified by circulating vitamin A or preformed vitamin A intake from supplements.

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