Evaluating [¹¹C]PBR28 PET for Monitoring Gut and Brain Inflammation in a Rat Model of Chemically Induced Colitis

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• 作者：E. Kurtys ; J. Doorduin ; U. L. M. Eisel…
• 关键词：Key WordsMacrophage ; Colitis ; 2 ; 4 ; 6 ; Trinitrobenzenesulfonic acid ; Neuroinflammation ; PET ; Imaging
• 刊名：Molecular Imaging and Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 页码：68-76
• 全文大小：2215KB
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：19

文摘

PurposeUlcerative colitis (UC) is a chronic inflammatory disease of the colon that affects an increasing number of patients. High comorbidity is observed between UC and other diseases in which inflammation may be involved, including brain diseases such as cognitive impairment, mental disorders, anxiety, and depression. To investigate the increased occurrence of these brain diseases in patients with UC, non-invasive methods for monitoring peripheral and central inflammation could be applied. Therefore, the goal of this study is to assess the feasibility of monitoring gut and brain inflammation in a rat model of chemically induced colitis by positron emission tomography (PET) with [11C]PBR28, a tracer targeting the translocator protein (TSPO), which is upregulated when microglia and macrophages are activated.