SMAD7, an antagonist of TGF-beta signaling, is a candidate of prenatal skeletal muscle development and weaning weight in pigs

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• 作者：Chaoju Hua ; Zishuai Wang ; Jianbing Zhang ; Xing Peng…
• 关键词：SMAD7 ; Skeletal muscle development ; miRNA ; 21 ; Association analysis ; Pig
• 刊名：Molecular Biology Reports
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：43
• 期：4
• 页码：241-251
• 全文大小：1,523 KB
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• 作者单位：Chaoju Hua (1)
  Zishuai Wang (1)
  Jianbing Zhang (3)
  Xing Peng (1)
  Xinhua Hou (1)
  Yalan Yang (1)
  Kui Li (1) (2)
  Zhonglin Tang (1) (2)
  
  1. The Key Laboratory for Domestic Animal Genetic Resources and Breeding of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Hai Dian, Beijing, 100193, People’s Republic of China
  3. Institute of Animal Science, Tianjin Agriculture University, Xi Qing, Tianjin, 300384, People’s Republic of China
  2. Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, People’s Republic of China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4978

文摘

SMAD7 promotes and enhances skeletal muscle differentiation by inhibiting transforming growth factor beta (TGF-β)/activin signaling and bone morphogenetic protein (BMP) pathways. However, its function, the mechanism regulating its translation, and its association with production meat traits remain unclear in pigs. In this study, we explored SMAD7 gene spatio-temporal and tissue distribution, conducted a single nucleotide polymorphism association analysis, and examined regulation of its expression during skeletal muscle development. We found that SMAD7 was positively related to TGF-β pathway genes and mainly expressed in prenatal developing muscle, and dual luciferase and western blot assays demonstrated that SMAD7 expression was regulated by miRNA-21 at the protein level via inhibition of mRNA translation. Finally, the association analysis showed that a single nucleotide mutation (Exon 4_28816;C/A) was significantly associated with the weaning weight of piglets among Yorkshire pigs. These data indicate that SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.