Evaluation of Histological and non-Invasive Methods for the Detection of Liver Fibrosis: The Values of Histological and Digital Morphometric Analysis, Liver Stiffness Measurement and APRI Score

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• 作者：T眉nde Hal谩sz ; G谩bor Horv谩th ; Andr谩s Kiss ; Gabriella P谩r…
• 关键词：Liver fibrosis ; Liver stiffness ; Digital morphometric analysis ; Liver biopsy
• 刊名：Pathology & Oncology Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：22
• 期：1
• 页码：1-6
• 全文大小：424 KB
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• 作者单位：T眉nde Hal谩sz (1) (2)
  G谩bor Horv谩th (3)
  Andr谩s Kiss (1)
  Gabriella P谩r (4)
  Andrea Szombati (5)
  Fanni Gelley (6)
  Bal谩zs Nemes (6)
  Istv谩n Kenessey (1)
  Violetta Piurk贸 (1)
  Zsuzsa Schaff (1) (7)
  
  1. Second Department of Pathology, Semmelweis University, Ulloi str 93, 1091, Budapest, Hungary
  2. Department of Pathology, Military Hospital, Budapest, Hungary
  3. Hepatology Center of Buda, Budapest, Hungary
  4. First Department of Medicine, Medical University of P茅cs, P茅cs, Hungary
  5. St. Istvan and St. Laszlo Hospital, Budapest, Hungary
  6. Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
  7. MTA-SE Tumor Progression Research Group, Hungarian Academy of Sciences, Budapest, Hungary
  
• 刊物主题：Cancer Research; Oncology; Pathology; Immunology; Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1532-2807

文摘

Prognosis and treatment of liver diseases mainly depend on the precise evaluation of the fibrosis. Comparisons were made between the results of Metavir fibrosis scores and digital morphometric analyses (DMA), liver stiffness (LS) values and aminotransferase-platelet ratio (APRI) scores, respectively. Liver biopsy specimens stained with Sirius red and analysed by morphometry, LS and APRI measurements were taken from 96 patients with chronic liver diseases (56 cases of viral hepatitis, 22 cases of autoimmune- and 18 of mixed origin). The strongest correlation was observed between Metavir score and DMA (r鈥?鈥?.75 p鈥?lt;鈥?.05), followed in decreasing order by LS and Metavir (r鈥?鈥?.61), LS and DMA (r鈥?鈥?.47) LS and APRI (r鈥?鈥?.35) and Metavir and APRI (r鈥?鈥?.24), respectively. DMA is a helpful additional tool for the histopathological evaluation of fibrosis, even when the sample size is small and especially in case of advanced fibrosis. The non-invasive methods showed good correlation with the histopathological methods; LS proved to be more accurate than APRI. The stronger correlation between LS values and Metavir scores, as well as the results of DMA in case of appropriate sample size were remarkable. Keywords Liver fibrosis Liver stiffness Digital morphometric analysis Liver biopsy