Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder

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• 作者：Melissa Kirkovski ; Peter G. Enticott…
• 关键词：Autism spectrum disorder ; Theory of mind ; Mentalizing network ; Sex differences ; Medial prefrontal cortex ; Temporo ; parietal junction ; Superior temporal sulcus ; Functional magnetic resonance imaging
• 刊名：Journal of Autism and Developmental Disorders
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：46
• 期：3
• 页码：954-963
• 全文大小：795 KB
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• 作者单位：Melissa Kirkovski (1) (2)
  Peter G. Enticott (1) (2)
  Matthew E. Hughes (3)
  Susan L. Rossell (1) (3)
  Paul B. Fitzgerald (1)
  
  1. Monash Alfred Psychiatry Research Centre, The Alfred and Central Clinical School, Monash University, Melbourne, VIC, Australia
  2. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Melbourne Burwood Campus, Building BC, Level 5, 221 Burwood Hwy, Burwood, VIC, 3125, Australia
  3. Brain and Psychological Science Research Centre, Faculty Health, Arts and Design, Swinburne University, Hawthorn, VIC, Australia
  
• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Child and School Psychology
  Pediatrics
  
• 出版者：Springer Netherlands
• ISSN：1573-3432

文摘

The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. Keywords Autism spectrum disorder Theory of mind Mentalizing network Sex differences Medial prefrontal cortex Temporo-parietal junction Superior temporal sulcus Functional magnetic resonance imaging