Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice
详细信息 查看全文
- 作者：Gunjan Dhawan Manocha ; Angela Marie Floden ; Kendra Lynn Puig…
- 关键词：Parkinson’s disease ; Humanized mice ; MPTP ; FK506 ; Neuroinflammation
- 刊名：Molecular Neurodegeneration
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：12
- 期：1
- 全文大小：3817KB
- 刊物主题：Neurosciences; Neurology; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1750-1326
- 卷排序：12
文摘
BackgroundReactive microglia have been associated with the histological changes that occur in Parkinson’s disease brains and mouse models of the disease. Multiple studies from autopsy brains have verified the presence of microgliosis in several brain regions including substantia nigra, striatum, hippocampus and various cortical areas. MPTP injections in rodents have also shown striato-nigral microgliosis correlating with the loss of dopaminergic neurons. However, consistent data with respect to cytokine and immune cell changes during Parkinson’s disease have not been fully defined.