Potential of Ca2+ in Mycobacterium tuberculosis H37Rv Pathogenesis and Survival
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- 作者：Somya Sharma ; Laxman S. Meena
- 关键词：Mycobacterium tuberculosis ; LAM ; Macrophages ; PE_PGRS ; Calmodulin
- 刊名：Applied Biochemistry and Biotechnology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：181
- 期：2
- 页码：762-771
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Biotechnology; Biochemistry, general;
- 出版者：Springer US
- ISSN：1559-0291
- 卷排序：181
文摘
The host-pathogen interaction and involvement of calcium (Ca2+) signaling in tuberculosis infection is crucial and plays a significant role in pathogenesis. Ca2+ is known as a ubiquitous second messenger that could control multiple processes and is included in cellular activities like division, motility, stress response, and signaling. However, Ca2+ is thought to be a regulative molecule in terms of TB infection but its binding relation with proteins/substrates molecules which are influenced with Ca2+ concentrations in host-pathogen interaction requires attention. So, in this review, our primary goal is to focus on some Ca2+ substrates/proteins and their imperative involvement in pathogenesis, which is unclear. We have discussed several Ca2+-binding substrate and protein that affect intracellular mechanism of infected host cell. The major involvement of these proteins/substrates including calmodulin (CaM), calpain, annexin, surfactant protein A (SP-A), surfactant protein D (SP-D), calprotectin (MRP8/14), and PE_PGRS family protein are considered to be significant; however, their detailed understanding in mycobacterium infection is limited. In this aspect, this study will help in adding up our understanding in TB biology and additionally in the development of new therapeutic approach to reduce TB pandemic worldwide.